Art

J-GLOBAL ID：201202274772056516   Reference number：12A0562471

The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts

ヒト線維芽細胞の非ウイルス性mRNA介在リプログラミングに関連する細胞毒性及び免疫原性ハードル

Author (9)： DREWS Katharina (Molecular Embryology and Aging Group, Dep. of Vertebrate Genomics, Max Planck Inst. for Molecular Genetics, Ihnestr. ...) ,  DREWS Katharina (Dep. of Biology, Chemistry and Pharmacy, Inst. of Chemistry and Biochemistry, Freie Universitaet Berlin, Takustr. 3 ...) ,  TAVERNIER Geertrui (Res. Group on Nanomedicines, Ghent Univ., Harelbekestraat 72, 9000 Ghent, BEL) ,  DEMEESTER Joseph (Res. Group on Nanomedicines, Ghent Univ., Harelbekestraat 72, 9000 Ghent, BEL) ,  LEHRACH Hans (Molecular Embryology and Aging Group, Dep. of Vertebrate Genomics, Max Planck Inst. for Molecular Genetics, Ihnestr. ...) ,  DE SMEDT Stefaan C. (Res. Group on Nanomedicines, Ghent Univ., Harelbekestraat 72, 9000 Ghent, BEL) ,  REJMAN Joanna (Res. Group on Nanomedicines, Ghent Univ., Harelbekestraat 72, 9000 Ghent, BEL) ,  ADJAYE James (Molecular Embryology and Aging Group, Dep. of Vertebrate Genomics, Max Planck Inst. for Molecular Genetics, Ihnestr. ...) ,  ADJAYE James (Inst. for Stem Cell Res. and Regenerative Medicine, Heinrich Heine Univ. Duesseldorf, Moorenstr. 5, 40225 ...)
Material： Biomaterials
Volume： 33  Issue： 16  Page： 4059-4068  Publication year： Jun. 2012 
JST Material Number： C0964B  ISSN： 0142-9612  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： gene introduction ,  Cell Differentiation ,  *cytotoxicity ,  *immunogenicity ,  *fibroblast ,  mRNA ,  Transfection ,  DNA binding protein ,  transcription factor ,  oncoprotein ,  adaptor protein ,  aromatic amine ,  aromatic ketone ,  unsaturated ketone ,  conjugated diene ,  unsaturated carboxylic acid ,  tertiary amine ,  nitrogen heterocyclic compound ,  aromatic chlorine compound ,  polynuclear aromatic compound ,  diamine ,  secondary amine ,  KLF4 ,  Sox2 ,  TRIF ,  *reprogramming ,  lipofection ,  nonviral gene transfer ,  Oct-4 ,  immune response ,  Proto-Oncogene Proteins c-myc ,  differentiation (biology) ,  developmental physiology
Semi thesaurus term： immunological reaction ,  c-Myc

JST classification (3)： Gene manipulation  (EC02050B) ,  Biological function  (EB03040U) ,  Immunological reaction in general  (ED03010T)

Substance index (2)： Trichostatin A ,  Chloroquine

Terms in the title (7)： ヒト ,  線維芽細胞 ,  ウイルス ,  mRNA ,  リプログラミング ,  細胞毒性 ,  免疫原性