Art

J-GLOBAL ID：201202277903050780   Reference number：12A1430022

STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjoegren’s syndrome

Tリンパ球におけるSTIM1およびSTIM2タンパク質の欠損が,外分泌腺自己免疫病であるSjoegren症候群の進行の根底にある

Author (9)： CHENG Kwong Tai (National Inst. Health, MD) ,  ALEVIZOS Ilias (National Inst. Health, MD) ,  LIU Xibao (National Inst. Health, MD) ,  SWAIM Wiliam D. (National Inst. Health, MD) ,  YIN Hongen (National Inst. Health, MD) ,  FESKE Stefan (New York Univ. Langone Medical Center, NY) ,  OH-HORA Masatsugu (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  OH-HORA Masatsugu (JST-PRESTO, Tokyo, JPN) ,  AMBUDKAR Indu S. (National Inst. Health, MD)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 109  Issue： 36  Page： 14544-14549  Publication year： Sep. 04, 2012 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *transmembrane protein ,  knockout mouse ,  *Sjoegren syndrome ,  *salivary gland disease ,  autoimmune disease ,  human ,  Phenotype ,  autoantibody ,  submaxillary gland ,  T cell ,  double knockout mouse ,  lymphocyte infiltration ,  *Primary Sjoegren syndrome ,  Signal Transduction ,  immune response ,  Ca2+ signaling ,  *STIM1 protein ,  laboratory animal ,  Mus musculus ,  *Inflammation ,  *collagen disease ,  *rheumatism ,  *Arthritis ,  *eye disease ,  *bone and joint disease ,  *mouth disease ,  *lacrimal apparatus disease ,  *joint disease ,  *Xerostomia ,  *connective tissue disease ,  *stomatognathic disease ,  *rheumatoid arthritis
Semi thesaurus term： cellular signal transduction ,  immunological reaction ,  T lymphocyte ,  STIM2蛋白質 ,  Calcium Signaling ,  *stromal interaction molecule 1 ,  disease of salivary gland

JST classification (3)： Biological function  (EB03040U) ,  Immunological reaction in general  (ED03010T) ,  Immunologic diseases,allergic diseases in general.  (GD04010C)

Terms in the title (8)： Tリンパ球 ,  STIM1 ,  STIM2 ,  タンパク質 ,  欠損 ,  外分泌腺 ,  自己免疫病 ,  Sjoegren症候群