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J-GLOBAL ID：201202280284922107   Reference number：12A0721281

Polycyclic Aromatic Hydrocarbons Activate CYP3A4 Gene Transcription through Human Pregnane X Receptor

多環芳香族炭化水素はヒトプレグナンX受容体を介してCYP3A4遺伝子の転写を活性化する

Author (7)： KUMAGAI Takeshi (Dep. of Environmental Health Sci., Tohoku Pharmaceutical Univ.) ,  SUZUKI Hiroyuki (Dep. of Environmental Health Sci., Tohoku Pharmaceutical Univ.) ,  SASAKI Takamitsu (Dep. of Environmental Health Sci., Tohoku Pharmaceutical Univ.) ,  SAKAGUCHI Shuhei (Dep. of Environmental Health Sci., Tohoku Pharmaceutical Univ.) ,  MIYAIRI Shinichi (Lab. of Organic Chemistry, School of Pharmacy, Nihon Univ.) ,  YAMAZOE Yasushi (Div. of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  NAGATA Kiyoshi (Dep. of Environmental Health Sci., Tohoku Pharmaceutical Univ.)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 27  Issue： 2  Page： 200-206 (J-STAGE)  Publication year： 2012 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *steroid hormone receptor ,...
Semi thesaurus term： CYP3A4 ,...

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JST classification (1)： Enzyme in general  (EB09010D)

Substance index (2)： 2,3,7,8-TCDD ,  Rifampin

Reference (40)：

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• 2) Nebert, D. W. and Russell, D. W.: Clinical importance of cytochromes P450. Lancet, 360: 1155–1162 (2002).
• 3) Thummel, K. E. and Wilkinson, G. R.: In vitro and in vivo drug interactiona involving human CYP3A. Annu. Rev. Pharmacol. Toxicol., 38: 389–430 (1998).
• 4) Quattrochi, L. C. and Guzelian, P. S.: CYP3A regulation: From pharmacology to nuclear receptors. Drug Metab. Dispos., 29: 615–622 (2001).
• 5) Thelen, K. and Dressman, J. B.: Cytochrome P450-mediated metabolism in the human gut wall. J. Pharm. Pharmacol., 61: 541–558 (2009).

Terms in the title (6)： 多環芳香族炭化水素 ,  ヒト ,  プレグナンX受容体 ,  CYP3A4遺伝子 ,  転写 ,  活性化