Art

J-GLOBAL ID：201202284074184532   Reference number：12A1050324

Cardiotoxic Local Anesthetics Increasingly Interact with Biomimetic Membranes under Ischemia-Like Acidic Conditions

心毒性局所麻酔薬は虚血様酸性条件下で生体模倣膜と益々相互作用する

Author (4)： TSUCHIYA Hironori (Dep. of Dental Basic Education, School of Dentistry, Asahi Univ.) ,  MIZOGAMI Maki (Dep. of Anesthesiology and Reanimatology, Fac. of Medical Sciences, Univ. of Fukui) ,  UENO Takahiro (Dep. of Anesthesiology, School of Dentistry, Asahi Univ.) ,  SHIGEMI Kenji (Dep. of Anesthesiology and Reanimatology, Fac. of Medical Sciences, Univ. of Fukui)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 35  Issue： 6  Page： 988-992 (J-STAGE)  Publication year： 2012 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *local anesthetic ,...
Semi thesaurus term： phospholipid membrane ,...

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JST classification (4)： Basic research of local anesthetics  (GW04020S) ,  Basic medicine on cardiovascular system  (GJ01020K) ,  Biochemistry of lipids in general  (EB05010B) ,  Toxicity of organic compounds  (GZ02030Y)

Substance index (4)： 1,2-Dipalmitoylphosphatidylcholine ,  Cholesterol ,  Bupivacaine ,  Lidocaine

Reference (26)：

• 1) Freysz M, Timour Q, Bertrix L, Loufoua-Moundanga J, Omar S, Faucon G. Enhancement by ischemia of the risk of cardiac disorders, especially fibrillation, in regional anesthesia with bupivacaine. Acta Anaesthesiol. Scand., 37, 350–356 (1993).
• 2) Pacini DJ, Boachie-Ansah G, Kane KA. Modification by hypoxia, hyperkalaemia and acidosis of the cardiac electrophysiological effects of a range of antiarrhythmic drugs. Br. J. Pharmacol., 107, 665–670 (1992).
• 3) Freysz M, Timour Q, Bertrix L, Loufoua J, Aupetit JF, Faucon G. Bupivacaine hastens the ischemia-induced decrease of the electrical ventricular fibrillation threshold. Anesth. Analg., 80, 657–663 (1995).
• 4) Tsibiribi P, Bui-Xuan C, Bui-Xuan B, Tabib A, Descotes J, Chevalier P, Gagnieu MC, Belkhiria M, Timour Q. The effects of ropivacaine at clinically relevant doses on myocardial ischemia in pigs. J. Anesth., 20, 341–343 (2006).
• 5) Bond JM, Chacon E, Herman B, Lemasters JJ. Intracellular pH and Ca²⁺ homeostasis in the pH paradox of reperfusion injury to neonatal rat cardiac myocytes. Am. J. Physiol., 265, C129–C137 (1993).

Terms in the title (6)： 心毒性 ,  局所麻酔薬 ,  虚血 ,  酸性条件 ,  生体模倣 ,  相互作用