Art

J-GLOBAL ID：201202288379518363   Reference number：12A1720324

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

リボソーム結合品質管理複合体は新生ペプチドの分解を誘発し,翻訳ストレスを伝達する

Author (33)： BRANDMAN Onn (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  BRANDMAN Onn (California Inst. for Quantitative Biomedical Res., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  BRANDMAN Onn (Howard Hughes Medical Inst., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  STEWART-ORNSTEIN Jacob (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  STEWART-ORNSTEIN Jacob (California Inst. for Quantitative Biomedical Res., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  STEWART-ORNSTEIN Jacob (Howard Hughes Medical Inst., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  WONG Daisy (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  WONG Daisy (California Inst. for Quantitative Biomedical Res., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  WONG Daisy (Howard Hughes Medical Inst., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  LARSON Adam (Dep. of Biochemistry and Biophysics, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  WILLIAMS Christopher C. (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  WILLIAMS Christopher C. (California Inst. for Quantitative Biomedical Res., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  WILLIAMS Christopher C. (Howard Hughes Medical Inst., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  LI Gene-wei (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  LI Gene-wei (California Inst. for Quantitative Biomedical Res., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  LI Gene-wei (Howard Hughes Medical Inst., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  ZHOU Sharleen (HHMI Mass Spectrometry Lab., Univ. of California, Berkeley, Berkeley, CA 94720, USA) ,  KING David (HHMI Mass Spectrometry Lab., Univ. of California, Berkeley, Berkeley, CA 94720, USA) ,  SHEN Peter S. (Dep. of Biochemistry and Huntsman Cancer Inst., Univ. of Utah School of Medicine, Salt Lake City, UT 84112, USA) ,  WEIBEZAHN Jimena (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  WEIBEZAHN Jimena (California Inst. for Quantitative Biomedical Res., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  WEIBEZAHN Jimena (Howard Hughes Medical Inst., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  DUNN Joshua G. (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  DUNN Joshua G. (California Inst. for Quantitative Biomedical Res., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  DUNN Joshua G. (Howard Hughes Medical Inst., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  ROUSKIN Silvi (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  ROUSKIN Silvi (California Inst. for Quantitative Biomedical Res., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  ROUSKIN Silvi (Howard Hughes Medical Inst., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  INADA Toshifumi (Graduate School of Pharmaceutical Sci., Tohoku Univ., Sendai 980-8578, JPN) ,  FROST Adam (Dep. of Biochemistry and Huntsman Cancer Inst., Univ. of Utah School of Medicine, Salt Lake City, UT 84112, USA) ,  WEISSMAN Jonathan S. (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  WEISSMAN Jonathan S. (California Inst. for Quantitative Biomedical Res., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  WEISSMAN Jonathan S. (Howard Hughes Medical Inst., Univ. of California, San Francisco, San Francisco, CA 94158, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 151  Issue： 5  Page： 1042-1054  Publication year： Nov. 21, 2012 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *quality control ,  *ribosome ,  translation (genetics) ,  *transcription factor ,  Saccharomyces cerevisiae ,  protein complex ,  protein kinase A ,  stress (physiology) ,  DNA binding protein ,  ATPase ,  Proteins ,  proteasome ,  proteolysis ,  polypeptide ,  *protein quality control ,  *HSF1 ,  Cdc48 ,  microorganism ,  Yeasts ,  Ascomycetous yeast
Semi thesaurus term： Msn2 ,  Msn4 ,  Cdc48 protein ,  Rqc1

JST classification (2)： Biological function  (EB03040U) ,  Gene expression  (EC02040Q)

Terms in the title (8)： リボソーム ,  品質管理 ,  複合体 ,  新生ペプチド ,  分解 ,  誘発 ,  翻訳 ,  ストレス