Art

J-GLOBAL ID：201202290825494656   Reference number：12A1426266

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

in vivoでの肝遺伝子抑制に対するsiRNA脂質ナノ粒子の効力を最大化する

Author (19)： JAYARAMAN Muthusamy (Alnylam Pharmaceuticals, MA, USA) ,  ANSELL Steven M. (AlCana Technol., BC, CAN) ,  MUI Barbara L. (AlCana Technol., BC, CAN) ,  TAM Ying K. (AlCana Technol., BC, CAN) ,  CHEN Jianxin (AlCana Technol., BC, CAN) ,  DU Xinyao (AlCana Technol., BC, CAN) ,  BUTLER David (Alnylam Pharmaceuticals, MA, USA) ,  ELTEPU Laxman (Alnylam Pharmaceuticals, MA, USA) ,  MATSUDA Shigeo (Alnylam Pharmaceuticals, MA, USA) ,  NARAYANANNAIR Jayaprakash K. (Alnylam Pharmaceuticals, MA, USA) ,  RAJEEV Kallanthottathil G. (Alnylam Pharmaceuticals, MA, USA) ,  HAFEZ Ismail M. (Univ. British Columbia, BC, CAN) ,  AKINC Akin (Alnylam Pharmaceuticals, MA, USA) ,  MAIER Martin A. (Alnylam Pharmaceuticals, MA, USA) ,  TRACY Mark A. (Alnylam Pharmaceuticals, MA, USA) ,  CULLIS Pieter R. (Univ. British Columbia, BC, CAN) ,  MADDEN Thomas D. (AlCana Technol., BC, CAN) ,  MANOHARAN Muthiah (Alnylam Pharmaceuticals, MA, USA) ,  HOPE Michael J. (AlCana Technol., BC, CAN)
Material： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition in English)
Volume： 51  Issue： 34  Page： 8529-8533  Publication year： 2012 
JST Material Number： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： siRNA ,  *nano particle ,  in vivo experiment ,  *gene introduction ,  hydrocarbon ,  length ,  *chemical bond ,  *hypercholesterolemia ,  *solid lipid nanoparticle ,  *linker ,  Suppression, Genetic ,  chain length ,  molecular genetic phenomenon ,  phenomenon ,  Genetic Phenomena
Semi thesaurus term： suppression(genetics) ,  *siRNA delivery ,  molecular length

JST classification (3)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Medical materials  (GA05040H) ,  Gene manipulation  (EC02050B)

Terms in the title (4)： 遺伝子抑制 ,  siRNA ,  脂質ナノ粒子 ,  最大化