Art

J-GLOBAL ID：201202291620866069   Reference number：12A1672600

New Cardenolides from the Seeds of Adonis aestivalis

Stephania venosaからのアルカロイド,クレバニンによるヒト癌細胞のG1停止及びアポトーシスの誘導

Author (6)： KUBO Satoshi (Dep. of Medicinal Pharmacognosy, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  KURODA Minpei (Dep. of Medicinal Pharmacognosy, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  MATSUO Yukiko (Dep. of Medicinal Pharmacognosy, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  MASATANI Daichi (Dep. of Medicinal Pharmacognosy, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  SAKAGAMI Hiroshi (Div. of Pharmacology, Dep. of Diagnostic and Therapeutic Sciences, School of Dentistry, Meikai Univ.) ,  MIMAKI Yoshihiro (Dep. of Medicinal Pharmacognosy, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 60  Issue： 10  Page： 1275-1282 (J-STAGE)  Publication year： 2012 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Menispermaceae ,...
Semi thesaurus term： *G1 arrest ,...

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JST classification (3)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of pharmacology of crude drugs  (GX06020J) ,  Experimental treatment for tumors  (GE02040Y)

Substance index (1)： (-)-Crebanine

Reference (22)：

• 1) Watanabe K., Mimaki Y., Sakuma C., Sashida Y., J. Nat. Prod., 66, 879–882 (2003).
• 2) Mimaki Y., Nadaoka I., Yasue M., Ohtake Y., Ikeda M., Watanabe K., Sashida Y., J. Nat. Prod., 69, 829–832 (2006).
• 3) Watanabe K., Mimaki Y., Sakagami H., Sashida Y., Chem. Pharm. Bull., 50, 121–125 (2002).
• 4) Watanabe K., Mimaki Y., Sakagami H., Sashida Y., J. Nat. Prod., 66, 236–241 (2003).
• 5) Mimaki Y., Yokosuka A., Hamanaka M., Sakuma C., Yamori T., Sashida Y., J. Nat. Prod., 67, 1511–1516 (2004).

Terms in the title (7)： Stephania ,  アルカロイド ,  クレバニン ,  ヒト ,  癌細胞 ,  アポトーシス ,  誘導