Art

J-GLOBAL ID：201202291876182370   Reference number：12A0238558

A Novel Diabetes Mellitus Mouse Model, MAFA-Deficient and Beta Cell-Specific MAFK-Overexpressing Hybrid Transgenic Mice, Developed Severe Diabetic Nephropathy and Improved with TCV-116 (Candesartan Cilexetil) Treatment

MAFAを欠損させβ細胞特異的MAFKを過剰発現した新規糖尿病マウスモデルのハイブリッドトランスジェニックマウスは重度の糖尿病性腎症を発症しTCV-116(カンデサルタンシレキセチル)処置で改善した

Author (8)： FUJITA Akiko (Dep. of Nephrology, Div. of Clinical Medicine, Fac. of Medicine, Univ. of Tsukuba) ,  YOH Keigyou (Dep. of Nephrology, Div. of Clinical Medicine, Fac. of Medicine, Univ. of Tsukuba) ,  SHIMOHATA Homare (Dep. of Nephrology, Tokyo Medical Univ. Ibaraki Medical Center) ,  MORITO Naoki (Dep. of Nephrology, Div. of Clinical Medicine, Fac. of Medicine, Univ. of Tsukuba) ,  OJIMA Masami (Dep. of Anatomy and Embryology, Div. of Biomedical Sci., Fac. of Medicine, Univ. of Tsukuba) ,  OKAMURA Midori (Dep. of Anatomy and Embryology, Div. of Biomedical Sci., Fac. of Medicine, Univ. of Tsukuba) ,  TAKAHASHI Satoru (Dep. of Anatomy and Embryology, Div. of Biomedical Sci., Fac. of Medicine, Univ. of Tsukuba) ,  YAMAGATA Kunihiro (Dep. of Nephrology, Div. of Clinical Medicine, Fac. of Medicine, Univ. of Tsukuba)
Material： Experimental Animals  (実験動物ニュース)
Volume： 61  Issue： 1  Page： 49-57 (J-STAGE)  Publication year： 2012 
JST Material Number： Z0755A  ISSN： 1341-1357  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： DNA binding protein ,...
Semi thesaurus term： MafA ,...

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JST classification (3)： Basic medicine on urogenital system  (GM01020T) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Basic research of drugs acting on urinary system  (GW11010R)

Substance index (1)： Candesartan cilexetil

Reference (35)：

• ANAN, F. Candesartan, an angiotensin II receptor blocker, improves left ventricular hypertrophy and insulin resistance. Metabolism. 2004, 53, 777-781
• BENKHELIFA, S. MafA, a novel member of the maf proto-oncogene family, displays developmental regulation and mitogenic capacity in avian neuroretina cells. Oncogene. 1998, 17, 247-254
• BREWSTER, U. C. The renin-angiotensin-aldosterone system and the kidney : effects on kidney disease. Am. J. Med. 2004, 116, 263-272
• BREYER, M. D. Mouse models of diabetic nephropathy. J. Am. Soc. Nephrol. 2005, 16, 27-45
• CERIELLO, A. New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy. Diabetes Care. 2003, 26, 1589-1596

Terms in the title (13)： MafA ,  欠損 ,  β細胞 ,  MafK ,  過剰発現 ,  糖尿病マウス ,  モデル ,  トランスジェニックマウス ,  糖尿病性腎症 ,  発症 ,  TCV-116 ,  カンデサルタンシレキセチル ,  処置