Art

J-GLOBAL ID：201202298905659690   Reference number：12A0040123

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

活性酸素種によるピルビン酸キナーゼM2の阻害は細胞の抗酸化応答に寄与する

Author (21)： ANASTASIOU Dimitrios (Beth Israel Deaconess Medical Center, MA, USA) ,  ANASTASIOU Dimitrios (Harvard Medical School, MA, USA) ,  POULOGIANNIS George (Beth Israel Deaconess Medical Center, MA, USA) ,  POULOGIANNIS George (Harvard Medical School, MA, USA) ,  ASARA John M. (Beth Israel Deaconess Medical Center, MA, USA) ,  ASARA John M. (Harvard Medical School, MA, USA) ,  BOXER Matthew B. (National Inst. Health, MD, USA) ,  JIANG Jian-kang (National Inst. Health, MD, USA) ,  SHEN Min (National Inst. Health, MD, USA) ,  BELLINGER Gary (Beth Israel Deaconess Medical Center, MA, USA) ,  BELLINGER Gary (Massachusetts Inst. Technol., MA, USA) ,  SASAKI Atsuo T. (Beth Israel Deaconess Medical Center, MA, USA) ,  SASAKI Atsuo T. (Harvard Medical School, MA, USA) ,  LOCASALE Jason W. (Beth Israel Deaconess Medical Center, MA, USA) ,  LOCASALE Jason W. (Harvard Medical School, MA, USA) ,  AULD Douglas S. (National Inst. Health, MD, USA) ,  THOMAS Craig J. (National Inst. Health, MD, USA) ,  VANDER HEIDEN Matthew G. (Harvard Medical School, MA, USA) ,  VANDER HEIDEN Matthew G. (Massachusetts Inst. Technol., MA, USA) ,  CANTLEY Lewis C. (Beth Israel Deaconess Medical Center, MA, USA) ,  CANTLEY Lewis C. (Harvard Medical School, MA, USA)
Material： Science
Volume： 334  Issue： 6060  Page： 1278-1283  Publication year： Dec. 02, 2011 
JST Material Number： E0078A  ISSN： 0036-8075  CODEN： SCIEA  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *active oxygen ,  *pyruvate kinase ,  *enzyme inhibition ,  *activity(property) ,  tumor cell ,  *cell physiology ,  concentration(ratio) ,  glycolytic pathway ,  *pentose phosphate cycle ,  oxidation-reduction potential ,  detoxication ,  *oxidative stress ,  *lung tumor ,  tumorigenesis
Semi thesaurus term： tumorigenesis ,  *antioxidant activity ,  *Cell Survival ,  intracellular concentration ,  reduction potential

JST classification (3)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Terms in the title (5)： 活性酸素種 ,  ピルビン酸キナーゼM2 ,  阻害 ,  細胞 ,  抗酸化応答