Research keywords (4):
insulin
, 糖輸送体
, ライブイメージング
, 細胞内輸送
Research theme for competitive and other funds (6):
2021 - 2024 インスリン分泌顆粒の動員過程を制御するしくみの定量理解
2020 - 2023 先端的蛍光技術を用いた分泌顆粒動態の計測法確立と調節機構の解明
2017 - 2019 Attempts for generating intracellular artificial protein complexes and modulating cellular functions with fluorescent nanoparticles
2014 - 2016 Establishement of simplified methods for analyzing intracellular single molecule behavior
2013 - 2016 Molecular and structural basis of insulin resistance revealed by high precision nanometry
2013 - 2016 Investigation of the Vps10p-family proteins and its sorting disorders in life-style-related diseases
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Papers (39):
Hiroyasu Hatakeyama, Tomomi Oshima, Shinichiro Ono, Yuichi Morimoto, Noriko Takahashi. Single-molecule analysis of intracellular insulin granule behavior and its application to analyzing cytoskeletal dependence and pathophysiological implications. Frontiers in Physiology. 2023. 14
Hiroyasu Hatakeyama, Makoto Kanzaki. Protocol for preparing sensor molecules and analyzing heterotypic endomembrane fusion in insulin-responsive cells using live-cell imaging. STAR protocols. 2022. 3. 4. 101726-101726
Hiroyasu Hatakeyama, Ko Kobayashi, Makoto Kanzaki. Three live-imaging techniques for comprehensively understanding the initial trigger for insulin-responsive intracellular GLUT4 trafficking. iScience. 2022. 25. 4. 104164-104164
Roles of Interleukin-1 in mediating the skeletal muscle activity
(The 17th Asian Academy of Craniomandibular Disorders (AACMD) congress 2017)
Roles of Interleukin-1 in the regulation of myoblast fusion and actin dynamics
(ASCB/EMBO 2017 2017)
Quantitative visualization of “life” -「生きている」をみる・はかる
(第2回FRIS/DIARE Joint Workshop 2017)
Identification of heterotypic endosomal fusion as an initial trigger for insulin-induced GLUT4 translocation in skeletal muscle revealed by comprehensive imaging analyses of GLUT4 behavior
(FASEB Summer Research Conference “Glucose Transport: Gateway to Metabolic Systems Biology” 2017)
Roles of IL-1α/β and Neutrophils in GLUT4 Translocation and Muscle Performance during Exercise
(FASEB Summer Research Conference “Glucose Transport: Gateway to Metabolic Systems Biology” 2017)