daisuke sakano

サカノダイスケ | daisuke sakano

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/40571039.ja.html

Research field (2)： Metabolism and endocrinology , Gastroenterology

Research keywords (3)：発生・分化 , 再生医学 , 細胞・組織

Research theme for competitive and other funds (5)：

2020 - 2023 モノアミンシグナルを介した膵島の機能性調節機構の解明
2017 - 2020 Elucidation of monoamine-GPCR signal-regulated pancreatic beta cell differentiation and maturation mechanism
2014 - 2017 Elucidation of pancreatic beta cell differentiation and maturation mechanism by monoamines
2012 - 2014 Small compounds promote differentiation of functional insulin producing cells
2010 - 2011 The establishment of a screening system for low molecular compounds forβcell inducing activity.

Papers (21)：

Hiraku Tokuma, Daisuke Sakano, Katsuya Tanabe, Yukio Tanizawa, Nobuaki Shiraki, Shoen Kume. Selective proteasome degradation of C-terminally-truncated human WFS1 in pancreatic beta cells. FEBS open bio. 2023. 13. 8. 1405-1414
Fumiya Uefune, Toru Aonishi, Tetsuya Kitaguchi, Harumi Takahashi, Susumu Seino, Daisuke Sakano, Shoen Kume. Dopamine Negatively Regulates Insulin Secretion Through Activation of D1-D2 Receptor Heteromer. DIABETES. 2022. 71. 9. 1946-1961
Daisuke Sakano, Fumiya Uefune, Hiraku Tokuma, Yuki Sonoda, Kumi Matsuura, Naoki Takeda, Naomi Nakagata, Kazuhiko Kume, Nobuaki Shiraki, Shoen Kume. VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet-Induced Stress. Diabetes. 2020. 69. 11. 2377-2391
Daisuke Sakano, Airi Inoue, Takayuki Enomoto, Mai Imasaka, Seiji Okada, Mutsumi Yokota, Masato Koike, Kimi Araki, Shoen Kume. Insulin2Q104del (Kuma) mutant mice develop diabetes with dominant inheritance. Scientific reports. 2020. 10. 1. 12187-12187
Ka-Cheuk Liu, Gunter Leuckx, Daisuke Sakano, Philip A Seymour, Charlotte L Mattsson, Linn Rautio, Willem Staels, Yannick Verdonck, Palle Serup, Shoen Kume, et al. Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors. Diabetes. 2018. 67. 1. 58-70

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MISC (30)：

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Work history (1)：

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