Rchr
J-GLOBAL ID：201301007600641153   Update date: Oct. 23, 2024

Miyazaki Takuro

ミヤザキ タクロウ | Miyazaki Takuro
Affiliation and department：
Showa University School of Medicine

About Showa University School of Medicine


Homepage URL  (1)： http://kaken.nii.ac.jp/d/r/80398693.ja.html
Research field  (4)： Nutrition and health science ,  Cardiology ,  Clinical pharmacy ,  Physiology
Research keywords  (7)： Obesity ,  macrophage ,  vascular biology ,  atherosclerosis ,  proteolysis ,  Vascular endothelial cells ,  Shear stress
Research theme for competitive and other funds  (25)：
  • 2023 - 2028 プラーク内出血とハプトグロビン遺伝子多型から見た新たな冠動脈イベント予防戦略
  • 2022 - 2026 Homeostatic regulation of metabolic organs by splicing factors and its clinical application
  • 2019 - 2022 Regulation of atheroscllerosis by lymphatic endothelial calpain sysmtems
  • 2021 - N/A
  • 2021 - N/A
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Papers (52)：
  • Kaoru Yanagisawa, Kazuyuki Miyamoto, Yoshihiro Wakayama, Satoru Arata, Keisuke Suzuki, Motoyasu Nakamura, Hiroki Yamaga, Takuro Miyazaki, Kazuho Honda, Kenji Dohi, et al. Exacerbation of Hepatic Damage in Endothelial Aquaporin 1 Transgenic Mice after Experimental Heatstroke. Biomedicines. 2024. 12. 9
  • Takuro Miyazaki. Calpain and Cardiometabolic Diseases. International Journal of Molecular Sciences. 2023. 24. 23. 16782-16782
  • Takuro Miyazaki, Yoshitaka Taketomi, Takayoshi Higashi, Hirokazu Ohtaki, Takashi Takaki, Koji Ohnishi, Masahiro Hosonuma, Nozomu Kono, Risako Akasu, Shogo Haraguchi, et al. Hypercholesterolemic Dysregulation of Calpain in Lymphatic Endothelial Cells Interferes With Regulatory T-Cell Stability and Trafficking. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022. 43. 2. e66-e82
  • Lymphatic dysfunction and atherogenesis. 2022. Vol.73. No.6. 575-579
  • Sumio Hayakawa, Atsushi Tamura, Nikita Nikiforov, Hiroyuki Koike, Fujimi Kudo, Yinglan Cheng, Takuro Miyazaki, Marina Kubekina, Tatiana V Kirichenko, Alexander N Orekhov, et al. Activated cholesterol metabolism is integral for innate macrophage responses by amplifying Myd88 signaling. JCI insight. 2022. 7. 22
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MISC (47)：
  • 宮崎拓郎. Emerging roles of splicing factors in metabolic diseases. Bio Clinica. 2024. 39. 9
  • 宮崎 拓郎, 宮崎 章. 【治療標的がみえてきた 脂質疾患学 がん、不妊症、免疫・神経・皮膚・代謝性疾患のメカニズムから臨床検体による診断、層別化まで】(第3章)脂質と多彩な疾患の深い関係 肥満・代謝性疾患 LDL修飾の最新知見から紐解く動脈硬化研究の現在. 実験医学. 2023. 41. 17. 2868-2873
  • 宮崎 拓郎, 赤須 里沙子, 宮崎 章. 血管内皮細胞におけるcalpain依存的なアミノ酸産生が脂肪肝形成におよぼす影響. 脂質生化学研究. 2022. 64. 181-184
  • 宮崎 拓郎. バイオメヂィカルサイエンスの最前線 生活習慣病に潜むタンパク質分解異常. 昭和学士会雑誌. 2022. 81. 6. 625-630
  • 宮崎 拓郎. 生化学で切り込む循環器研究の最前線 カルパインプロテアーゼシステムによる動脈硬化性疾患の制御. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [3S05m-03]
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Books (2)：
  • 実験医学増刊Vol.41 No.17 治療標的がみえてきた脂質疾患学 がん、不妊症、免疫・神経・皮膚・代謝性疾患のメカニズムから臨床検体による診断、層別化まで
    羊土社 2023 ISBN:9784758104142
  • mRNA
    2023 ISBN:9784861049378
Lectures and oral presentations  (32)：
  • Calpain and cardiometabolic disorders
    (12th General Meeting of the International Proteolysis Society: Session5 Calpain and proteases 2023)
  • Impact of dysfunctional intracellular proteolysis systems on cardiometabolic disease
    (CVMW2022 JVBMO symposium 1 2022)
  • PROTEOLYTIC PRODUCTION OF FREE AMINO ACIDS BY CONVENTIONAL CALPAINS IN VASCULAR ENDOTHELIAL CELLS AUGMENTS OBESITY-INDUCED HEPATIC STEATOSIS
    (FASEB Science Research Conference 2022 The Biology of Calpains in Health and Disease Conference 2022)
  • Calpain and atherosclerosis
    (The 94th Annual Meeting of the Japanese Biochemical Society 2021)
  • Obesity-induced hepatic steatosis harbors proteolytic production of branched-chain amino acids in vascular endothelial cells
    (19th International Symposium on Atherosclerosis 2021)
ｍore...
Education (2)：
  • 1999 - 2001 Showa University School of Pharmacological sciences Department of Pharmacology
  • 1995 - 1999 Showa University School of Pharmaceutical Sciences
Professional career (1)：
  • PhD. (Showa University)
Work history (4)：
  • 2019/06 - 現在 Showa University Dept of Biochemistry, Sch of Medicine Associate Professor
  • 2015/05 - 2019/05 Showa University School of Medicine Associate Professor
  • 2011/04 - 2015/04 Showa University Assistant Professor
  • 2004/11 - 2011/03 Showa University Radio Isotope Center at 1st Building,Showa University
Committee career (5)：
  • 2023/02 - 現在 Frontiers in Cardiovascular Medicine Review Editor
  • 2022/07 - 現在 Japan Atherosclerosis Society Associate Editor (Journal of Atherosclerosis and Thrombosis)
  • 2018 - 現在 Japanese Vascular Biology and Medicine Organization Councilor
  • 2016 - 現在 Japan Atherosclerosis Society Councilor
  • 2022 - Japanese Vascular Biology and Medicine Oeganization 30th annual meeting Program Committee
Awards (24)：
  • 2021/03 - 2020年度 内藤記念科学奨励金・研究助成
  • 2021 - 公益財団法人 持田記念医学薬学振興財団 2021年度 研究助成金
  • 2019/10 - ブリストル・マイヤーズ スクイブ株式会社 2019年度 研究助成
  • 2018/11 - 鈴木謙三記念医科学応用研究財団 平成30年度調査研究助成
  • 2018/10 - 金原一郎記念医学医療振興財団 第33回基礎医学医療研究助成金
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Association Membership(s) (5)：
THE JAPANESE CONFERENCE ON THE BIOCHEMISRTY OF LIPIDS ,  JAPANESE VASCULAR AND MEDICINE ORGANIZATION ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  JAPAN ATHEROSCLEROSIS SOCIETY ,  The Plemacantieal Society at danam
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