Rchr
J-GLOBAL ID：201301015905582150
Update date: Apr. 17, 2024
Nagai Yoshinori
ナガイ ヨシノリ | Nagai Yoshinori
Affiliation and department：
Homepage URL (1)：
https://www.pu-toyama.ac.jp/PH/nagai/index.html
Research field (4)：
Pathobiochemistry
, Experimental pathology
, Laboratory animal science
, Immunology
Research keywords (12)：
非アルコール性脂肪性肝炎
, 自然免疫
, 免疫学
, Toll-like receptor
, 肥満
, 脂質
, 造血分化
, 自己免疫病
, リンパ球
, 炎症
, クラススイッチ変換
, 骨髄由来多能性前駆細胞
Research theme for competitive and other funds (21)：
- 2022 - 2025 肝臓マクロファージサブセット解析から迫る新規線維化亢進NASHマウスの病態解明
- 2019 - 2022 Development of novel autoimmune therapeutics that selectively inhibit TLR7 activation
- 2016 - 2019 Adrenoleukodystrophy: effect of bone marrow transplantation in abcd1-deficient mouse
- 2016 - 2019 Free fatty acids-mediated dynamic changes of neutrophils induce adipose tissue inflammation
- 2015 - 2018 Study on the drug development for tumor immunotherapy based on immune-restoring activity of a plant ingredient betulin.
- 2015 - 2018 Search for the target molecule of the licorice component inhibiting NLRP3 inflammasome and development into drug discovery research
- 2015 - 2017 Elucidation of the mechanism of the innate immune signal that induces hypothalamic inflammation and feeding dysfunction
- 2013 - 2016 生活習慣病における自然免疫系と代謝内分泌系との機能的クロストークの解明
- 2012 - 2015 A mechanism of action of a plant ingredient betulin on restoring the suppression of antitumor activity of immune cells by TGF-beta or PGE2.
- 2012 - 2015 Analysis of innate IL-5 producing cells in immune responses and chronic inflammation
- 2013 - 2014 自然免疫シグナル分子による摂食反応・肥満制御機構の解明
- 2012 - 2014 Search for innate immune molecules and compounds that regulate adipose tissue inflammation
- 2012 - 2013 脂肪組織炎症を制御するRP105/MD-1の機能解析及び内因性リガンドの探索
- 2011 - 2012 Spatiotemporal control of allergy and non-infectious inflammation and their regulation by natural products
- 2010 - 2011 脂肪組織の自然炎症におけるRP105/MD-1シグナルと可溶型MD-1の機能解析
- 2009 - 2011 Roles of lipid-recognition molecules in autoimmune diseases
- 2009 - 2011 Elucidation of the source of pluripotent progenitor cells in systemic inflammatory mouse model
- 2008 - 2010 Roles of cytokines and TLRs in lymphocyte activation and differentiation
- 2005 - 2009 Enhancement of Th1 and antitumor immunity by Ag85B and Peptide-25.
- 2007 - 2008 Differentiation and maturation of innate immune cells via TLR
- 2004 - 2008 Investigation of regulatory mechanisms for homeostasis and activation of lymphocyte
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Papers (89)：
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Naoya Igarashi, Kaichi Kasai, Yuki Tada, Koudai Kani, Miyuna Kato, Shun Takano, Kana Goto, Yudai Matsuura, Mayuko Ichimura-Shimizu, Shiro Watanabe, et al. Impacts of liver macrophages, gut microbiota, and bile acid metabolism on the differences in iHFC diet-induced MASH progression between TSNO and TSOD mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2024
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Fumitake Usui-Kawanishi, Koudai Kani, Tadayoshi Karasawa, Hiroe Honda, Nobuyuki Takayama, Masafumi Takahashi, Kiyoshi Takatsu, Yoshinori Nagai. Isoliquiritigenin inhibits NLRP3 inflammasome activation with CAPS mutations by suppressing caspase-1 activation and mutated NLRP3 aggregation. Genes to cells : devoted to molecular & cellular mechanisms. 2024
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Nana Makiuchi, Shun Takano, Yuki Tada, Kaichi Kasai, Naoya Igarashi, Koudai Kani, Miyuna Kato, Kana Goto, Yudai Matsuura, Mayuko Ichimura-Shimizu, et al. Dynamics of Liver Macrophage Subsets in a Novel Mouse Model of Non-Alcoholic Steatohepatitis Using C57BL/6 Mice. Biomedicines. 2023. 11. 10
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Yoshiyuki Watanabe, Shiho Fujisaka, Yoshitomo Morinaga, Shiro Watanabe, Allah Nawaz, Hideki Hatta, Tomonobu Kado, Ayumi Nishimura, Muhammad Bilal, Muhammad Rahil Aslam, et al. Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice. Molecular metabolism. 2023. 101797-101797
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Riko Ishibashi, Rio Matsuhisa, Mio Nomoto, Seita Chudan, Miyu Nishikawa, Yoshiaki Tabuchi, Shinichi Ikushiro, Yoshinori Nagai, Yukihiro Furusawa. Effect of Oral Administration of Polyethylene Glycol 400 on Gut Microbiota Composition and Diet-Induced Obesity in Mice. Microorganisms. 2023
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MISC (73)：
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高野 峻, 清水 真祐子, 常山 幸一, 長井 良憲. 抗生剤投与による腸内細菌叢変化がNASHの発症・病態に与える影響の解析. 肝臓. 2023. 64. Suppl.1. A363-A363
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五十嵐 直哉, 清水 真祐子, 常山 幸一, 長井 良憲. 肝臓構成細胞に着目した非アルコール性脂肪性肝炎進展の差異に関する研究. 肝臓. 2023. 64. Suppl.1. A409-A409
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葛西 海智, 常山 幸一, 清水 真祐子, 長井 良憲. NASH線維化亢進モデルマウス"3-Fマウス"における腸内細菌叢及び胆汁酸組成の変化. 肝臓. 2022. 63. Suppl.1. A402-A402
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葛西 海智, 古澤 之裕, 多田 有希, 五十嵐 直哉, 渡辺 志朗, 市村 真祐子[清水], 常山 幸一, 長井 良憲. 線維化亢進非アルコール性脂肪性肝炎モデルマウス"3-Fマウス"における腸内細菌叢及び胆汁酸組成の解析. 日本薬学会年会要旨集. 2022. 142年会. 28I-am10S
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石橋璃子, 古澤之裕, 本田裕恵, 渡邉康春, 藤坂志帆, 戸邉一之, 高津聖志, 栗原新, 田渕圭章, 長井良憲. Effect of isoliquiritigenin on gut bacteria, adipose tissue inflammation, and metabolic syndrome. 日本薬学会年会要旨集(Web). 2022. 142nd
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Patents (6)：
Education (3)：
- 1998 - 2002 Saga Medical School
- 1989 - 1995 Saga Medical School
- 1985 - 1988 福岡県立明善高等学校
Professional career (1)：
Work history (10)：
- 2018/04 - 現在 Toyama Prefectural University Faculty of Engineering
- 2016/04 - 2019/03 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences for Research
- 2013/10 - 2017/03 Japan Science and Technology Agency
- 2007/04 - 2016/03 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences for Research
- 2006/03 - 2007/03 The University of Tokyo The Institute of Medical Science
- 2004/03 - 2006/03 Oklahoma Medical Research Foundation Immunobiology & Cancer Associate Research Scientist, Senior Research Scientist
- 2002/02 - 2004/03 The University of Tokyo The Institute of Medical Science
- 1997/06 - 1998/03 麻生飯塚病院 内科 専修医
- 1996/05 - 1997/05 佐賀県立病院好生館 内科 研修医
- 1995/05 - 1996/04 Saga Medical School
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Committee career (1)：
Awards (7)：
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