Rchr
J-GLOBAL ID：201301022501680448
Update date: Sep. 27, 2024
Taisuke Nakahama
ナカハマ タイスケ | Taisuke Nakahama
Affiliation and department：
Job title：
助教
Research field (3)：
Molecular biology
, Immunology
, Neuroscience - general
Research keywords (3)：
RNA編集
, エカルディ・グティエール症候群 (AGS)
, Z型RNA
Research theme for competitive and other funds (5)：
- 2021 - 2024 RNA編集不全によって引き起こされる遺伝性脳症の病態形成機構の解明
- 2018 - 2021 Elucidation of the mechanism underlying the regulation of adaptive immunity by endogenous double-stranded RNA
- 2015 - 2018 The role of RNA editing in Th17 cell differentiation
- 2013 - 2016 慢性関節リウマチの病態解明に向けたAhrによるTh17細胞分化制御機構の解析
- 2012 - 2014 AhrによるmicroRNAの発現調節を介したTh17細胞の分化制御機構の解析
Papers (22)：
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Yanfang Xing*, Taisuke Nakahama*#, Yuke Wu, Maal Inoue, Jung In Kim, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara# (Co-first author*, Corresponding author#). RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing. Journal of Biological Chemistry. 2023. 104840-104840
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Taisuke Nakahama, Yukio Kawahara. The RNA-editing enzyme ADAR1: a regulatory hub that tunes multiple dsRNA-sensing pathways. International Immunology. 2022. 35. 3. 123-133
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Maal Inoue*, Taisuke Nakahama*, Ryuichiro Yamasaki, Toshiharu Shibuya, Jung In Kim, Hiroyuki Todo, Yanfang Xing, Yuki Kato, Eiichi Morii, Yukio Kawahara (Co-first author*). An Aicardi-Goutières Syndrome-Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice. Journal of immunology (Baltimore, Md. : 1950). 2021
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Taisuke Nakahama, Yukio Kawahara. Deciphering the Biological Significance of ADAR1-Z-RNA Interactions. International journal of molecular sciences. 2021. 22. 21
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Taisuke Nakahama, Yuki Kato, Toshiharu Shibuya, Maal Inoue, Jung In Kim, Tuangtong Vongpipatana, Hiroyuki Todo, Yanfang Xing, Yukio Kawahara. Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy. Immunity. 2021. 54. 9. 1976-1988.e7
ｍore...
MISC (7)：
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中濱泰祐, 河原行郎. The roles of RNA editing in viral infection. 月刊臨床免疫・アレルギー科. 2023. 80. 4
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中濱泰祐. Regulation of dsRNA-sensing systems by the RNA-editing enzyme ADAR1. 月刊臨床免疫・アレルギー科. 2023. 80. 5
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中濱泰祐, 河原行郎. Reduced RNA editing activity of ADAR1 p150 induces Aicardi-Goutieres syndrome-like symptoms in mice. 月刊臨床免疫・アレルギー科. 2022. 77. 6. 737-743
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中濱泰祐, 河原行郎. Innate immune responses to left-handed Z-RNAs. 実験医学. 2022. 40. 4. 544-549
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中濱泰祐, 河原行郎. Type I interferonopathies caused by dysregulation of RNA metabolism. 実験医学. 2022. 40. 15
ｍore...
Lectures and oral presentations (2)：
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RNA編集酵素ADAR1による自然免疫制御の新たな展開
(第1回 Kansai RNA Club 2023)
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Regulatory mechanisms underlying ADAR1 p150-mediated RNA editing
(ABZ meeting 2022 (A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA) 2022)
Work history (3)：
- 2016 - 現在 Osaka University
- 2013 - 2016 Osaka University
- 2012 - 2013 Osaka University WPI Immunology Frontier Research Center
Awards (1)：
- 2022 - 日本免疫学会 日本免疫学会研究奨励賞
Association Membership(s) (2)：
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