Itoh Yukihiro

イトウユキヒロ | Itoh Yukihiro

Affiliation and department：
Homepage URL (1)： https://www.sanken.osaka-u.ac.jp/labs/cmc/yukihiro-itoh/

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (4)： Biological organic chemistry , ケミカルバイオロジー , 創薬化学 , 有機化学

Research theme for competitive and other funds (7)：

2022 - 2026 クリックケミストリーに基づく生物活性化合物創製法の確立
2021 - 2024 Development of innovative drug candidates by target guided synthesis
2020 - 2023 RNA分解誘導化合物の開発とその薬学的応用
2019 - 2021 ユビキチン化タンパク質ならびにその連結様式を解析するためのケミカルプローブ創製
2017 - 2020 Identification of artificial ubiquitin compounds and their application study

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Papers (76)：

Yosuke Ota, Yukihiro Itoh, Yuri Takada, Yasunobu Yamashita, Chenliang Hu, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, Takayoshi Suzuki. Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells. Bioorganic & medicinal chemistry. 2024. 100. 117632-117632
Mitsuhiro Terao, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki. Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity. Bioorganic & medicinal chemistry. 2024. 98. 117579-117579
Haiyan Li, Ayako Kawatake-Kuno, Hiromichi Inaba, Yuka Miyake, Yukihiro Itoh, Takatoshi Ueki, Naoya Oishi, Toshiya Murai, Takayoshi Suzuki, Shusaku Uchida. Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice. Neuron. 2024
Yuri Takada, Kyohei Adachi, Yuka Fujinaga, Yasunobu Yamashita, Yukihiro Itoh, Takayoshi Suzuki. A Structure-Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 1. Chemical & pharmaceutical bulletin. 2024. 72. 2. 155-160
Atika Nurani, Yasunobu Yamashita, Yuuki Taki, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki. Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning. Chemical & pharmaceutical bulletin. 2024. 72. 2. 173-178

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MISC (9)：

Toru Komatsu, Yukihiro Itoh. Challenges of young chemists to be global. Yakugaku Zasshi. 2019. 139. 2. 185-186
Youhei Sohma, Yukihiro Itoh. Chemical biology for pharmaceutical sciences (novel ideas for “drug” discovery). Yakugaku Zasshi. 2017. 137. 3. 281-282
Shuichiro Tsukamoto, Yoshitake Sakae, Yukihiro Itoh, Takayoshi Suzuki, Yuko Okamoto. Study of Ligand Binding Selectivity of Histone Deacetylases by Replica-Exchange Umbrella Sampling Molecular Dynamics Simulations. BIOPHYSICAL JOURNAL. 2016. 110. 3. 544A-545A
伊藤幸裕, 粟飯原圭佑, MELLINI Paolo, 東條敏史, 太田庸介, 津元裕樹, SOLOMON Viswas Raja, ZHAN Peng, 鈴木美紀, 小笠原大介, et al. ヒドラジン構造を持つペプチド性LSD1阻害薬の創製. メディシナルケミストリーシンポジウム講演要旨集. 2016. 34th
石川稔, 伊藤幸裕, 内藤幹彦, 橋本祐一. 2-II-24 細胞内レチノイド結合タンパク質の分解を誘導するレチノイン酸連結化合物の創製(一般演題,日本ビタミン学会第62回大会発表要旨). ビタミン. 2010. 84. 4. 189-189

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Professional career (1)：

Work history (3)：

2020/06 - 現在 Osaka University The Institute of Scientific and Industrial Research associate professor
2020/06 - 現在 Kyoto Prefectural University of Medicine
2019/04 - 2020/05 Kyoto Prefectural University of Medicine

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