Itoh Yukihiro

イトウユキヒロ | Itoh Yukihiro

Affiliation and department：
Homepage URL (1)： https://www.sanken.osaka-u.ac.jp/labs/cmc/yukihiro-itoh/

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (4)： Biological organic chemistry , ケミカルバイオロジー , 創薬化学 , 有機化学

Research theme for competitive and other funds (9)：

2024 - 2027 Development of chimera molecules targeting epigenetic complexes
2022 - 2026 クリックケミストリーに基づく生物活性化合物創製法の確立
2023 - 2025 分子接着剤を用いた超効率的な組織再生誘導
2021 - 2024 Development of innovative drug candidates by target guided synthesis
2020 - 2023 RNA分解誘導化合物の開発とその薬学的応用

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Papers (77)：

Tetsuya Iida, Yukihiro Itoh, Yukari Takahashi, Yuka Miyake, Farzad Zamani, Yasunobu Yamashita, Yuri Takada, Toshiki Akiyama, Jun Ibaraki, Kyoka Okuda, et al. Identification of Proteolysis Targeting Chimeras (PROTACs) for Lysine Demethylase 5 and Their Neurite Outgrowth-Promoting Activity. Chemical and Pharmaceutical Bulletin. 2024. 72. 7. 638-647
Siyao Ni, Yuri Takada, Takaaki Ando, Shengwang Yu, Yasunobu Yamashita, Yukari Takahashi, Miho Sawada, Makoto Oba, Yukihiro Itoh, Takayoshi Suzuki. Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule. Bioorganic & medicinal chemistry letters. 2024. 105. 129759-129759
Yosuke Ota, Yukihiro Itoh, Yuri Takada, Yasunobu Yamashita, Chenliang Hu, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, Takayoshi Suzuki. Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells. Bioorganic & medicinal chemistry. 2024. 100. 117632-117632
Mitsuhiro Terao, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki. Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity. Bioorganic & medicinal chemistry. 2024. 98. 117579-117579
Haiyan Li, Ayako Kawatake-Kuno, Hiromichi Inaba, Yuka Miyake, Yukihiro Itoh, Takatoshi Ueki, Naoya Oishi, Toshiya Murai, Takayoshi Suzuki, Shusaku Uchida. Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice. Neuron. 2024

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MISC (13)：

伊藤幸裕, 高田悠里, 山下泰信, 鈴木孝禎. Drug modalities for inhibition of protein-protein interactions. 実験医学. 2024. 42. 2
Yamashita Yasunobu, Takada Yuri, Itoh Yukihiro, Suzuki Takayoshi. Discovery of HDAC8-selective inhibitors and their application to PROTACs. MEDCHEM NEWS. 2023. 33. 4. 181-186
Toru Komatsu, Yukihiro Itoh. Challenges of young chemists to be global. Yakugaku Zasshi. 2019. 139. 2. 185-186
Youhei Sohma, Yukihiro Itoh. Chemical biology for pharmaceutical sciences (novel ideas for “drug” discovery). Yakugaku Zasshi. 2017. 137. 3. 281-282
Shuichiro Tsukamoto, Yoshitake Sakae, Yukihiro Itoh, Takayoshi Suzuki, Yuko Okamoto. Study of Ligand Binding Selectivity of Histone Deacetylases by Replica-Exchange Umbrella Sampling Molecular Dynamics Simulations. BIOPHYSICAL JOURNAL. 2016. 110. 3. 544A-545A

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Professional career (1)：

博士(薬学) (東京大学)

Work history (3)：

2020/06 - 現在 Osaka University The Institute of Scientific and Industrial Research associate professor
2020/06 - 現在 Kyoto Prefectural University of Medicine
2019/04 - 2020/05 Kyoto Prefectural University of Medicine

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