Yasuyuki Fujita

フジタヤスユキ | Yasuyuki Fujita

Homepage URL (1)： http://kaken.nii.ac.jp/d/r/50580974.ja.html

Research field (2)： Medical biochemistry , Cell biology

Research keywords (5)：新規癌治療法 , 癌 , Cell Cometition , 細胞培養 , 上皮細胞

Research theme for competitive and other funds (12)：

2021 - 2026 細胞競合の普遍的制御分子の同定とその動作機序の解明
2021 - 2026 Understanding multicellular autonomy by competitive cell-cell communications
2021 - 2026 Elucidation of prevalent molecular mechanisms for cell competition
2020 - 2022 Integrated understanding of intercellular communication and contraction forces
2018 - 2021 Elucidation of molecular mechanisms regulating cell competition and contact inhibition

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Papers (95)：

Estelle Gauquelin, Keisuke Kuromiya, Toshinori Namba, Keisuke Ikawa, Yasuyuki Fujita, Shuji Ishihara, Kaoru Sugimura. Mechanical convergence in mixed populations of mammalian epithelial cells. The European physical journal. E, Soft matter. 2024. 47. 3. 21-21
Shoko Ito, Keisuke Kuromiya, Miho Sekai, Hiroaki Sako, Kazuhito Sai, Riho Morikawa, Yohei Mukai, Yoko Ida, Moe Anzai, Susumu Ishikawa, et al. Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 43. e2307118120
Kazuki Nakai, Hancheng Lin, Shotaro Yamano, Shinya Tanaka, Sho Kitamoto, Kenta Sakuma, Junpei Kurauchi, Eilma Akter, Masamitsu Konno, Jun Koseki, et al. Wnt activation-induced disturbance of cell competition causes diffuse invasion of transformed cells through upregulation of NF-κB-mediated MMP21. Nature Communications. 2022. 14. 1
Takanobu Shirai, Miho Sekai, Kei Kozawa, Nanami Sato, Nobuyuki Tanimura, Shunsuke Kon, Tomohiro Matsumoto, Takeru Murakami, Shoko Ito, Andrew Tilston-Lunel, et al. Basal extrusion of single-oncogenic mutant cells induces dome-like structures with altered microenvironments. Cancer Science. 2022. 113. 11. 3710-3721
Kentaro Kajiwara, Ping Kuan Chen, Yuichi Abe, Satoru Okuda, Shunsuke Kon, Jun Adachi, Takeshi Tomonaga, Yasuyuki Fujita, Masato Okada. Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition. Current Biology. 2022. 32. 16. 3460-3476.e6

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MISC (15)：

山田壮平, 別所康全, 藤田恭之, 細川陽一郎, 松井貴輝. Signal propagation in short-range extrudes abnormal cells from epithelial sheets in animals. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
田守洋一郎, 藤田恭之. 細胞競合と補償的細胞成長による組織恒常性維持. 生化学. 2019. 91. 2
小橋功紀, 鳴海利香, 釜崎とも子, 藤田恭之. 多段階発がんにおける細胞競合現象の勝者・敗者の入れ替わり. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
EDAC (epithelial defense against cancer). 2016. 67. 2. 95-100
釜崎とも子, 藤田恭之. 細胞競合の基本原理とその破綻 Ras変異細胞と正常上皮細胞間に生じる細胞競合. 医学のあゆみ. 2016. 257. 4

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Professional career (1)：

博士(内科学) (京都大学)

Work history (2)：

2020/04 - 現在 Kyoto University
2010/04 - 2020/03 Hokkaido University Institute for Genetic Medicine

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