Hata Saori

ハタサオリ | Hata Saori

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/40581012.ja.html

Research field (1)： Pharmaceuticals - health and biochemistry

Research keywords (3)： γセクレターゼ , 診断マーカー , アルツハイマー病

Research theme for competitive and other funds (6)：

2018 - 2021 Pathogenesis of Alzheimer's disease based on vesicular transport system in neuron
2018 - 2021 アルツハイマー病関連ペプチドp3-Alcの神経細胞への作用メカニズムの解明
2015 - 2017 Alzheimer's disease-related peptides as a biomarker for diagnosis in early stage Alzheimer's disease
2012 - 2014 Analysis of p3-Alc peptides, the novel biomarker for Alzheimer's disease
2010 - 2011 Analysis of p3-Alc, metabolic product of Alcadein

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Papers (41)：

Keiko Honda, Hiroo Takahashi, Saori Hata, Ruriko Abe, Takashi Saito, Takaomi C Saido, Hidenori Taru, Yuriko Sobu, Kanae Ando, Tohru Yamamoto, et al. Suppression of the amyloidogenic metabolism of APP and the accumulation of Aβ by alcadein α in the brain during aging. Scientific reports. 2024. 14. 1. 18471-18471
Yuzuha Shiraki, Monet Mitsuma, Ritsuko Takada, Saori Hata, Akira Kitamura, Shinji Takada, Masataka Kinjo, Hidenori Taru, Ulrike C Müller, Tohru Yamamoto, et al. Axonal transport of Frizzled5 by Alcadein α-containing vesicles is associated with kinesin-1. Molecular biology of the cell. 2023. 34. 11. ar110
Saori Hata, Haruka Saito, Takeharu Kakiuchi, Dai Fukumoto, Shigeyuki Yamamoto, Kensaku Kasuga, Ayano Kimura, Koichi Moteki, Ruriko Abe, Shungo Adachi, et al. Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide. EMBO molecular medicine. 2023. 15. 5. e17052
Keiko Honda, Yuhki Saito, Haruka Saito, Megumi Toyoda, Ruriko Abe, Takashi Saito, Takaomi C Saido, Makoto Michikawa, Hidenori Taru, Yuriko Sobu, et al. Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging. Neurobiology of aging. 2023. 123. 63-74
Toshiharu Suzuki, Yuriko Sobu, Saori Hata. γ-Secretase structure and activity are modified by alterations in its membrane localization and ambient environment. Journal of biochemistry. 2022. 171. 3. 253-256

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MISC (29)：

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Education (1)：

Work history (2)：

Awards (3)：

Association Membership(s) (2)：

日本生化学会 , 日本認知症学会

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