J-GLOBAL ID:201301039658214475   Update date: Dec. 09, 2019

Toyoaki Natsume

ナツメ トヨアキ | Toyoaki Natsume
Affiliation and department:
Job title: Assistant Professor
Other affiliations (1):
Homepage URL  (2): https://www.nig.ac.jp/labs/MolFunc/Jpn/https://www.nig.ac.jp/labs/MolFunc/Eng/
Research field  (3): Genetics/Chromosome dynamics ,  Cell biology ,  Molecular biology
Research keywords  (6): Chromosome replication ,  Chromosome segregation ,  SMC complex ,  Cell cycle ,  Protein degradation ,  Genome editing
Papers (19):
  • Yoshiba S, Tsuchiya Y, Ohta M, Gupta A, Shiratsuchi G, Nozaki Y, Ashikawa T, Fujiwara T, Natsume T, Kanemaki M, Kitagawa D. HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates. Journal of cell science. 2019
  • Yesbolatova A, Natsume T, Hayashi KI, Kanemaki MT. Generation of conditional auxin-inducible degron (AID) cells and tight control of degron-fused proteins using the degradation inhibitor auxinole. Methods (San Diego, Calif.). 2019
  • Morii I, Iwabuchi Y, Mori S, Suekuni M, Natsume T, Yoshida K, Sugimoto N, Kanemaki MT, Fujita M. Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib. Cancer science. 2019
  • Goto H, Natsume T, Kanemaki MT, Kaito A, Wang S, Gabazza EC, Inagaki M, Mizoguchi A. Chk1-mediated Cdc25A degradation as a critical mechanism for normal cell-cycle progression. Journal of cell science. 2019
  • Okumura M, Natsume T, Kanemaki MT, Kiyomitsu T. Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble. eLife. 2018. 7
Lectures and oral presentations  (18):
  • Artificial destruction of active DNA replication forks reveals the HR-dependent fork recovery involving Mcm8-9
    (BMB2015 2015)
  • A PCR-based tagging method for generation of human conditional mutants by use of the auxin-inducible degron technology
    (Genome Engineering: The CRISPR/Cas Revolution 2015)
  • 人為的複製フォーク破壊システムを用いた ヒト細胞におけるフォーク再生機構の解析
    (第23回 DNA 複製・組換え・修復ワークショップ研究会 2015)
  • 人為的複製フォーク破壊システムを用いた ヒト細胞におけるフォーク再生機構の解析
    (第33回染色体ワークショップ ・第14回核ダイナミクス研究会 2016)
  • Rapid protein depletion in human cells by auxin-inducible degron (AID) tagging with short homology donors
    (第68回日本細胞生物学会大会 2016)
Education (3):
  • 1997 - 2001 Shinshu University Faculty of Science Department of Biological Sciences
  • 2001 - 2003 Shinshu University Graduate School of Science and Technology Department of Geosphere and Biosphere Science
  • 2003 - 2006 The Graduate University for Advanced Studies (SOKENDAI) School of Life Science Department of Genetics
Professional career (1):
  • phD (The Graduate University for Advanced Studies (SOKENDAI))
Work history (4):
  • 2006/04 - 2007/03 National Institute of Genetics Postdoctoral fellow
  • 2007/04 - 2013/03 University of Dundee (United Kingdom) Postdoctoral fellow
  • 2013/04 - 2016/08 National Institute of Genetics Postdoctoral fellow
  • 2016/09 - 現在 National Institute of Genetics Assistant professor
Association Membership(s) (3):
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