Rchr
J-GLOBAL ID:201301039658214475   Update date: May. 16, 2021

Natsume Toyoaki

ナツメ トヨアキ | Natsume Toyoaki
Affiliation and department:
Job title: 助教
Other affiliations (1):
Homepage URL  (2): https://www.nig.ac.jp/labs/MolFunc/Jpn/https://www.nig.ac.jp/labs/MolFunc/Eng/
Research field  (3): Genetics ,  Cell biology ,  Molecular biology
Research keywords  (7): SMC5/6 ,  SMC complex ,  Genome editing ,  Protein degradation ,  Cell cycle ,  Chromosome segregation ,  Chromosome replication
Research theme for competitive and other funds  (4):
  • 2019 - 2022 ヒトSMC5/6複合体の網羅的アンバイアス解析:オーキシンデグロン法を中心に
  • 2017 - 2018 瞬時に分解すれば見えてくる、MCMヘリカーゼとコヒーシンの共役と多彩な機能
  • 2015 - 2016 「非通常型DNA複製」におけるMCMヘリカーゼファミリーの役割分担の解析
  • 2013 - 2014 ゲノム編集とデグロン法によるヒト新細胞遺伝学を応用した複製フォーク再生機構の解明
Papers (24):
  • Kenji Iemura, Toyoaki Natsume, Kayoko Maehara, Masato T Kanemaki, Kozo Tanaka. Chromosome oscillation promotes Aurora A-dependent Hec1 phosphorylation and mitotic fidelity. The Journal of cell biology. 2021. 220. 7
  • Kyle N Klein, Peiyao A Zhao, Xiaowen Lyu, Takayo Sasaki, Daniel A Bartlett, Amar M Singh, Ipek Tasan, Meng Zhang, Lotte P Watts, Shin-Ichiro Hiraga, et al. Replication timing maintains the global epigenetic state in human cells. Science (New York, N.Y.). 2021. 372. 6540. 371-378
  • Takahiko Murayama, Yasuto Takeuchi, Kaoru Yamawaki, Toyoaki Natsume, Li Mengjiao, Rojas-Chaverra N Marcela, Tatsunori Nishimura, Yuta Kogure, Asuka Nakata, Kana Tominaga, et al. MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells. Cancer science. 2020
  • Lotte P Watts, Toyoaki Natsume, Yuichiro Saito, Javier Garzon, Qianqian Dong, Lora Boteva, Nick Gilbert, Masato T Kanemaki, Shin-ichiro Hiraga, Anne D Donaldson. The RIF1-Long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress. eLife. 2020
  • Andrés Bueno Venegas, Toyoaki Natsume, Masato Kanemaki, Ian D Hickson. Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase. Cell reports. 2020. 31. 3. 107533-107533
more...
Patents (1):
Lectures and oral presentations  (21):
  • DNA topology-dependent regulation of chromosome transactions by human SMC5/6
    (第2回日本遺伝学会春季分科会 2020)
  • ヒトSMC5/6と染色体トランスアクションにおけるDNAトポロジカルストレス:DNAの絡まりと超らせん構造
    (第37回染色体ワークショップ・第18回核ダイナミクス研究会 2019)
  • 第三のSMC複合体、SMC5/6の染色体トランスアクションにおける役割〜DNAトポロジカルストレスの観点から
    (第42回日本分子生物学会年会 2019)
  • Human SMC5/6 and DNA topological stress during chromosome transactions
    (EMBO Workshop: DNA topology and topoisomerases in genome dynamics 2019)
  • Elucidating a fundamental role of human SMC5/6 in chromosome transactions: from the viewpoint of DNA topological stress
    (EMBO Workshop: Organization of bacterial and eukaryotic genomes by SMC complexes 2019)
more...
Education (3):
  • 2003 - 2006 The Graduate University for Advanced Studies (SOKENDAI) Department of Genetics
  • 2001 - 2003 Shinshu University Department of Geosphere and Biosphere Science
  • 1997 - 2001 Shinshu University Department of Biological Sciences
Professional career (1):
  • phD (The Graduate University for Advanced Studies (SOKENDAI))
Work history (4):
  • 2016/09 - 現在 National Institute of Genetics Molecular Cell Engineering Laboratory, Department of Chromosome Science Assistant professor
  • 2013/04 - 2016/08 National Institute of Genetics Molecular Function Laboratory, Center for Frontier Research Postdoctoral fellow
  • 2007/04 - 2013/03 University of Dundee (United Kingdom) Centre for Gene Regulation & Expression, College of Life Sciences Postdoctoral fellow
  • 2006/04 - 2007/03 National Institute of Genetics Division of Mutagenesis, Department of Molecular Genetics Postdoctoral fellow
Awards (4):
  • 2018/03 - 稲盛財団 研究助成
  • 2017/12 - 第一三共生命科学研究振興財団 研究助成
  • 2017/11 - 持田記念医学薬学振興財団 研究助成金
  • 2017/10 - 住友財団 基礎科学研究助成
Association Membership(s) (3):
JAPAN SOCIETY FOR CELL BIOLOGY ,  THE GENETICS SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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