ose toyoyuki

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/80380525.ja.html

Research field (1)： Structural biochemistry

Research keywords (13)：生物物理 , 蛋白質工学 , 免疫 , 蛋白質 , NMR , 中性子 , シグナル伝達 , 結晶構造解析 , 構造解析 , structural biology , protein chemistry , molecular interaction , cellular molecular biology

Research theme for competitive and other funds (20)：

2021 - 2026 Studies on molecular mechanism of effector-mediated establishment of host specificity in plant pathogens and their application
2022 - 2024 世界初IDP型酵素の存在意義と構造形成機構の解明
2021 - 2024 Molecular basis of counteraction against the JAK-STAT signaling pathway by virus
2021 - 2024 新規に開発したBLLナノ構造体による、タンパク質結晶核形成過程の研究
2019 - 2023 Antibodies targeting dynamic epitopes generated by posttranslational protein glycosylation

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Papers (73)：

Yuto Sasaki, Kodai Saitoh, Kota Kagohashi, Toyoyuki Ose, Shoya Kawahara, Yuichi Kitai, Ryuta Muromoto, Yuichi Sekine, Michiko Ichii, Akihiko Yoshimura, et al. STAP-2-Derived Peptide Suppresses TCR-Mediated Signals to Initiate Immune Responses. The Journal of Immunology. 2023
Hang Wang, Xiaomei Sun, Wataru Saburi, Saki Hashiguchi, Jian Yu, Toyoyuki Ose, Haruhide Mori, Min Yao. Structural insights into the substrate specificity and activity of a novel mannose 2-epimerase from Runella slithyformis. Acta crystallographica. Section D, Structural biology. 2023. 79. Pt 7. 585-595
Masato Ishizaka, Minghao Chen, Shun Narai, Yoshikazu Tanaka, Toyoyuki Ose, Masaki Horitani, Min Yao. Quick and Spontaneous Transformation between [3Fe-4S] and [4Fe-4S] Iron-Sulfur Clusters in the tRNA-Thiolation Enzyme TtuA. International Journal of Molecular Sciences. 2023. 24. 1. 833-833
Hajime Wakui, Yasuhiro Yokoi, Chieko Horidome, Toyoyuki Ose, Min Yao, Yoshikazu Tanaka, Hiroshi Hinou, Shin-Ichiro Nishimura. Structural and molecular insight into antibody recognition of dynamic neoepitopes in membrane tethered MUC1 of pancreatic cancer cells and secreted exosomes. RSC Chemical Biology. 2023
Taiga Maemoto, Yuichi Kitai, Haruka Shoji, Runa Takahashi, Shunsuke Yamada, Shiho Takei, Daiki Ito, Ryuta Muromoto, Jun-ichi Kashiwakura, Haruka Handa, et al. A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling. Journal of Biological Chemistry, in press. 2022. 299. 1. 102724-102724

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MISC (113)：

南未来, 杉山葵, 武川祐一郎, 姚閔, 姚閔, 廣瀬未果, 杉田征彦, 尾瀬農之, 尾瀬農之. 狂犬病ウイルスPタンパク質によるSTAT阻害機構の解明. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
碓井拓哉, 大江花, 中村彰良, 尾瀬農之, 尾瀬農之, YAO Min, YAO Min. Structure determination of protein-tRNA complex using AlphaFold2 predicted model. Photon Factory News. 2022. 40. 3
南未来, 杉山葵, 野間井智, JIANG Xinxin, 前仲勝実, YAO Min, 尾瀬農之. 狂犬病ウイルスP蛋白質による宿主の免疫経路阻害機構の解明. 日本蛋白質科学会年会プログラム・要旨集. 2021. 21st
杉山葵, 野間井智, JIANG Xinxin, 南未来, 前仲勝実, 伊藤直人, GOOLEY Paul R., MOSELEY Gregory W., YAO Min, 尾瀬農之, et al. 病原性理解のためのLyssavirus P蛋白質C末端ドメイン構造解析. 日本蛋白質科学会年会プログラム・要旨集. 2021. 21st
木本円花, 永野悠馬, 杉山葵, 姚閔, 田所高志, 前仲勝実, 尾瀬農之. 麻疹ウイルスVタンパク質によるType I IFN経路阻害機構の解明. 日本結晶学会年会講演要旨集. 2021. 2021

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Education (5)：

2000 - 2003 日本学術振興会特別研究員(DC1)
2000 - 2003 Hokkaido University
1998 - 2000 Hokkaido University Faculty of Science
1995 - 1998 Hokkaido University School of Science
1994 - 1995 Hokkaido University

Professional career (1)：

博士(理学) (北海道大学)

Work history (8)：

2018/10 - 2022/03 科学技術振興機構さきがけ「量子技術を適用した生命科学基盤の創出」領域研究者
2022/01 - 北海道大学大学院先端生命科学研究院教授
2017/06 - 2021/12 Hokkaido University Faculty of Advanced Life Science
2010/04 - 2017/05 Hokkaido University Faculty of Pharmaceutical Sciences
2008/04 - 2010/03 Hokkaido University Faculty of Advanced Life Science

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