Ito Genta

イトウゲンタ | Ito Genta

Affiliation and department：
Job title： Senior Assistant Professor
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/10431892.ja.html

Research field (6)： Structural biochemistry , Functional biochemistry , Neuropathology , Neurology , Cell biology , Pharmaceuticals - health and biochemistry

Research keywords (7)： LRRK2 , Leucine-rich repease kinase 2 , Parkinson's disease , Alzheimer's disease , Amyloid β , kinase , GTP-binding protein

Research theme for competitive and other funds (7)：

2021 - 2024 パーキンソン病発症におけるLRRK2異常活性化メカニズムとその病的意義の解明
2019 - 2023 認知症発症機構における神経変性プロセスの鍵を握る細胞病態の解明
2017 - 2020 Elucidation of the molecular pathogenesis of Parkinson disease by uncovering the LRRK2-Rab pathway
2010 - 2015 Elucidation of the molecular pathology of Alzheimer's disease focusing on the synapses toward therapies
2012 - 2013 Membrane localization of LRRK2, a causative gene for familial Parkinson's

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Papers (34)：

Fumiaki Yoshida, Ryota Nagatomo, Shun Utsunomiya, Misaki Kimura, Shiyori Shun, Rena Kono, Yuma Kato, Yosuke Nao, Kazuma Maeda, Ryuta Koyama, et al. Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons. Translational psychiatry. 2024. 14. 1. 448-448
Genta Ito, Taisuke Tomita, Naoko Utsunomiya-Tate. Effects of bound nucleotides on the secondary structure, thermal stability, and phosphorylation of Rab3A. Biochemical and biophysical research communications. 2024. 723. 150199-150199
Genta Ito, Taisuke Tomita, Naoko Utsunomiya-Tate. LRRK2-mediated phosphorylation and thermal stability of Rab12 are regulated by bound nucleotides. Biochemical and biophysical research communications. 2023. 667. 43-49
Genta Ito, Naoko Utsunomiya-Tate. Overview of the Impact of Pathogenic LRRK2 Mutations in Parkinson’s Disease. Biomolecules. 2023
Kyohei Ito, Miho Araki, Yuta Katai, Yuki Nishimura, Sota Imotani, Haruki Inoue, Genta Ito, Taisuke Tomita. Pathogenic LRRK2 compromises the subcellular distribution of lysosomes in a Rab12-RILPL1-dependent manner. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023. 37. 5. e22930

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MISC (11)：

富田泰輔, 富田泰輔, 吉田文明, 熊詩若, 高鳥翔, 伊藤弦太, 伊藤弦太. 自閉症モデルマウスにおけるシナプス形成異常関連分子Lingo2の代謝機構解析. 日本病態プロテアーゼ学会学術集会プログラム抄録集. 2023. 28th
伊藤弦太, 伊藤弦太, 伊藤恭平, 荒木美保, 片井悠太, 西村佑紀, 芋谷颯太, 井上晴幾, 楯直子, 富田泰輔, et al. Regulation of lysosomal positioning by LRRK2, a protein kinase responsible for Parkinson’s disease. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
伊藤弦太, 富田泰輔, 富田泰輔, 楯直子. Rab12のヌクレオチド結合状態がLRRK2によるリン酸化と二次構造に与える影響の解析. 日本生化学会大会(Web). 2023. 96th
伊藤恭平, 荒木美保, 片井悠太, 西村佑紀, 井上晴幾, 伊藤弦太, 伊藤弦太, 富田泰輔, 富田泰輔. パーキンソン病原因遺伝子LRRK2が引き起こすリソソーム局在変化. 日本生化学会大会(Web). 2022. 95th
徐楽佳, 伊藤弦太, 伊藤弦太, 富田泰輔, 富田泰輔. パーキンソン病リスク遺伝子Rab29近傍タンパク質の網羅的同定と機能解析. 日本生化学会大会(Web). 2022. 95th

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Books (4)：

Experimental models of Parkinson's disease
Humana Press 2021 ISBN:9781071614945
神経・筋・精神/麻酔・鎮痛
中山書店 2019 ISBN:9784521744513
認知症の早期診断技術と進行抑制/予防薬・機能性食品の開発
技術情報協会 2019 ISBN:9784861047442
脳神経科学イラストレイテッド : 分子・細胞から実験技術まで
羊土社 2013 ISBN:9784758120401

Lectures and oral presentations (48)：

パーキンソン病原因キナーゼLRRK2によるリソソーム局在制御機構の解明
(第46回日本分子生物学会年会 2023)
Comprehensive identification of proximal proteins and functional analysis of Rab29
(Neuroscience 2023)
Regulation of intracellular lysosomal positioning by LRRK2
(Neuroscience 2023)
Rab12のヌクレオチド結合状態がLRRK2によるリン酸化と二次構造に与える影響
(第96回日本生化学会大会 2023)
パーキンソン病関連タンパク質Rab12の二次構造とLRRK2によるリン酸化に関する解析
(日本薬学会第143年会 2023)

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Education (2)：

2003 - 2006 University of Tokyo Graduate School of Pharmaceutical Sciences
1999 - 2003 University of Tokyo School of Pharmaceutical Sciences

Professional career (3)：

Ph.D. (Pharmaceutical Sciences) (The University of Tokyo)
MSc (Pharmaceutical Sciences) (The University of Tokyo)
BSc (Pharmaceutical Sciences) (The University of Tokyo)

Work history (9)：

2021/07 - 現在 Teikyo University Faculty of Pharmaceutical Sciences Senior Assistant Professor
2021/07 - 2024/03 The University of Tokyo Graduate School of Pharmaceutical Sciences
2021/07 - 2024/03 The University of Tokyo Faculty of Pharmaceutical Sciences Visiting Scientist
2017/09 - 2021/06 University of Tokyo Graduate School of Pharmaceutical Sciences Project Lecturer
2016/07 - 2017/08 The University of Tokyo Project Assistant Professor

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Association Membership(s) (7)：

Japanese Electrophoresis Society , Japanese Society for Dementia Research , The Pharmaceutical Society of Japan , The Japan Neuroscience Society , The Molecular Biology Society of Japan , Society for Neuroscience , The Japanese Biochemical Society

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