Tatsuya Ohhata

オオハタタツヤ | Tatsuya Ohhata

Affiliation and department：
Job title： Assistant professor
Homepage URL (1)： https://www.hama-med.ac.jp/education/fac-med/dept/mol-biol/faculty/index.html

Research field (1)： Molecular biology

Research keywords (5)： Epigenetics , X chromosome inactivation , long non-coding RNA , antisense RNA , Data science

Research theme for competitive and other funds (7)：

2022 - 2026 Cancer cell fate control by long-chain ncRNAs that regulate the gene specificity of epigenome factors
2021 - 2023 Molecular mechanisms of development of malignant female cancers associated with X-chromosome reactivation
2020 - 2023 TGFβに応答する機能性cis-NATs群の生理・分子機構の解明
2016 - 2020 Elucidation of transcription-coupled facultative heterochromatin dynamics
2016 - 2018 Regulatory mechanism of homologous recombination in a Sex-chromosome-dependent manner

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Papers (41)：

Takahito Suzuki, Satoshi Sakai, Kosuke Ota, Mika Yoshida, Chiharu Uchida, Hiroyuki Niida, Takafumi Suda, Masatoshi Kitagawa, Tatsuya Ohhata. Expression of Tumor Suppressor FHIT Is Regulated by the LINC00173-SNAIL Axis in Human Lung Adenocarcinoma. International journal of molecular sciences. 2023. 24. 23
Maya Suzuki, Satoshi Sakai, Kosuke Ota, Yuki Bando, Chiharu Uchida, Hiroyuki Niida, Masatoshi Kitagawa, Tatsuya Ohhata. CCIVR2 facilitates comprehensive identification of both overlapping and non-overlapping antisense transcripts within specified regions. Scientific reports. 2023. 13. 1. 14807-14807
Chiharu Uchida, Hiroyuki Niida, Satoshi Sakai, Kenta Iijima, Kyoko Kitagawa, Tatsuya Ohhata, Bunsyo Shiotani, Masatoshi Kitagawa. p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2023. 1870. 6. 119484-119484
Kosuke Ota, Satoshi Sakai, Tatsuya Ohhata, Takahito Suzuki, Chiharu Uchida, Hiroyuki Niida, Masatoshi Kitagawa. APOBEC3B expression is promoted by lincNMR collaborating with TGF-β-Smad pathway. Carcinogenesis. 2022
Tatsuya Ohhata, Maya Suzuki, Satoshi Sakai, Kosuke Ota, Hazuki Yokota, Chiharu Uchida, Hiroyuki Niida, Masatoshi Kitagawa. CCIVR facilitates comprehensive identification of cis-natural antisense transcripts with their structural characteristics and expression profiles. Scientific Reports. 2022. 12. 1. 15525-15525

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MISC (5)：

Tatsuya Ohhata, Mika Matsumoto, Martin Leeb, Shinwa Shibata, Kyoko Kitagawa, Hiroyuki Niida, Masatoshi Kitagawa, Anton Wutz. Molecular dissection of Xist repression mechanisms in mouse ES cells. GENES & GENETIC SYSTEMS. 2014. 89. 6. 308-308
原田雅教, 神武洋二郎, 大畑樹也, 北川恭子, 丹伊田浩之, 松浦駿, 船井和仁, 椙村春彦, 須田隆文, 北川雅敏. ヒト非小細胞肺癌においてYB-1はサイクリンD1の転写を促進する(YB-1 promotes transcription of cyclin D1 in human non-small-cell lung cancers). 日本呼吸器学会誌. 2014. 3. 増刊. 185-185
M. Harada, Y. Kotake, T. Ohhata, K. Kitagawa, H. Niida, S. Matsuura, K. Funai, H. Sugimura, T. Suda, M. Kitagawa. Yb-1 Promotes Transcription Of Cyclin D1 In Human Non-Small-Cell Lung Cancers. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2014. 189
Yuko Hoki, Tatsuya Ohhata, Hiroyuki Sasaki, Takahashi Sado. A partial loss of function mutation in the mechanism of X chromosome inactivation. GENES & GENETIC SYSTEMS. 2009. 84. 6. 442-442
佐渡敬, 大畑樹也. マウス胚体外組織におけるインプリント型X染色体不活性化 (特集ゲノムインプリンティング--その仕組みと生物学的意義,そして疾患とのかかわり). モレキュラ-メディシン. 2005. 42. 2. 173-180

Awards (2)：

2009/08 - Gordon Research Conference (GRC) Epigenetics Best poster awards Functional window of Tsix in imprinted X-inactivation
2005/09 - 日本遺伝学会ベストペーパー賞 Xist発現制御におけるプロモーター領域のアンチセンス転写の意義

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