Watanabe Yo-hei

ワタナベヨウヘイ | Watanabe Yo-hei

Affiliation and department：

Research field (2)： Biophysics , Functional biochemistry

Research keywords (11)： ClpB , 脱凝集 , 凝集体 , AAA , 分子シャペロン , DnaK , 蛋白質 , 酵素の作用機作と調節 , FtsH , おれたたみ , シャペロン

Research theme for competitive and other funds (3)：

2009 - 2011 Structural change and function of ClpB chaperone disaggregase
2007 - 2011 Protein handling by molecular chaperones
2006 - 2008 Reactivation of aggregated proteins by the ring-shaped molecular chaperone ClpB

Papers (19)：

Aono S, Haruna Y, Watanabe YH, Mochida S, Takeda K. The fission yeast Greatwall-Endosulfine pathway is required for proper quiescence/G<sub>0</sub> phase entry and maintenance. Genes to cells : devoted to molecular & cellular mechanisms. 2019. 24. 2. 172-186
Sugita S, Watanabe K, Hashimoto K, Niwa T, Uemura E, Taguchi H, Watanabe YH. Electrostatic interactions between middle domain motif-1 and the AAA1 module of the bacterial ClpB chaperone are essential for protein disaggregation. The Journal of biological chemistry. 2018. 293. 50. 19228-19239
Takayuki Uchihashi, Yo-hei Watanabe, Yosuke Nakazaki, Takashi Yamasaki, Hiroki Watanabe, Takahiro Maruno, Kentaro Ishii, Susumu Uchiyama, Chihong Song, Kazuyoshi Murata, et al. Dynamic structural states of CIpB involved in its disaggregation function. NATURE COMMUNICATIONS. 2018. 9. 1. 2147
Sayaka Hayashi, Yosuke Nakazaki, Kei Kagii, Hiromi Imamura, Yo-hei Watanabe. Fusion protein analysis reveals the precise regulation between Hsp70 and Hsp100 during protein disaggregation. SCIENTIFIC REPORTS. 2017. 7. 1. 8648
Takashi Yamasaki, Yukiko Oohata, Toshiki Nakamura, Yo-hei Watanabe. Analysis of the Cooperative ATPase Cycle of the AAA plus Chaperone ClpB from Thermus thermophilus by Using Ordered Heterohexamers with an Alternating Subunit Arrangement. JOURNAL OF BIOLOGICAL CHEMISTRY. 2015. 290. 15. 9789-9800

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MISC (2)：

Lectures and oral presentations (6)：

Motion and regulation of ClpB disaggregase
(第92回日本生化学会大会 2019)
Polypeptides protruded from the surface of protein aggregation influence the efficiency of disaggregation by molecular chaperones
(生物物理(Web) 2016)
凝集体をほどくAAA+シャペロンClpBの作動原理
(日本分子生物学会年会プログラム・要旨集(Web) 2016)
ClpB-DnaK脱凝集シャペロンに見られる,自己集合・自己組織化による機能獲得
(日本生化学会大会(Web) 2015)
分子シャペロンClpBの機能と構造変化
(日本蛋白質科学会年会プログラム・要旨集 2006)

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Professional career (1)：

Work history (3)：

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