Ken Takahashi

タカハシケン | Ken Takahashi

Homepage URL (1)： http://kaken.nii.ac.jp/d/r/60594372.ja.html

Research field (2)： Immunology , Gastroenterology

Research keywords (5)： Innate immunity , Immunology , Hepatology , Gastroenterology , Cnacer immunity

Research theme for competitive and other funds (6)：

2023 - 2026 Development of neoadjuvant immunotherapy for gastrointestinal cancer using in situ vaccine incorporating photoimmunotherapy.
2020 - 2023 Preclinical study of near-infrared photoimmunotherapy for pancreatic cancer that incorporates nanoparticulate TLR9 agonist K3-SPG
2021 - 2022 Practical Application Study of AI-Assisted Ultrasound System in Liver Tumors
2017 - 2020 Preclinical study of in situ vaccine immunotherapy for hepatocellular carcinoma targeting TLR9 and RIG-I
2013 - 2016 Comprehensive analysis of immune response in hapatitis B using novel disease mouse model

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Papers (105)：

Masayuki Ueno, Haruhiko Takeda, Atsushi Takai, Hiroki Morimura, Norihiro Nishijima, Satoru Iwamoto, Shunsuke Okuyama, Makoto Umeda, Takeshi Seta, Atsuyuki Ikeda, et al. CRAFITY score as a predictive marker for refractoriness to atezolizumab plus bevacizumab therapy in hepatocellular carcinoma: a multicenter retrospective study. Journal of gastroenterology. 2024
Hiroyuki Yoshida, Masahiro Shiokawa, Takeshi Kuwada, Yuya Muramoto, Sakiko Ota, Yoshihiro Nishikawa, Hirona Maeda, Nobuyuki Kakiuchi, Kanako Okamoto, Hajime Yamazaki, et al. Anti-integrin αvβ6 autoantibodies in patients with primary sclerosing cholangitis. Journal of gastroenterology. 2023. 58. 8. 778-789
Soichi Arasawa, Haruhiko Takeda, Atsushi Takai, Eriko Iguchi, Yuji Eso, Takahiro Shimizu, Ken Takahashi, Taiki Yamashita, Yoshihide Ueda, Hiroyuki Marusawa, et al. Evolutional transition of HBV genome during the persistent infection determined by single-molecule real-time sequencing. Hepatology communications. 2023. 7. 3. e0047
中野重治, 高井淳, 上野真行, 網野遙, 井上貴裕, 伊藤卓彦, 寺村茉利, 三嶋眞紗子, 熊谷健, 井口恵里子, et al. ミスマッチ修復遺伝子MSH2の欠損は炎症性肝発癌を促進する. 日本消化器病学会雑誌. 2022. 119. 臨増大会. A771-A771
Takaaki Yoshikawa, Atsushi Yamauchi, Ryuhei Hamasaki, Yuki Mori, Kazuki Osawa, Ryo Ito, Yuya Kawai, Souta Nakagami, Shunjiro Azuma, Toshihiro Morita, et al. The Safety and Clinical Validity of Endoscopic Submucosal Dissection for Early Gastric Cancer in Patients Aged More Than 85 Years. Cancers. 2022. 14. 14

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MISC (54)：

西尾太宏, 小山幸法, 小木曾聡, 楊知明, 福光剣, 石井隆道, 恵荘裕嗣, 高井淳, 高橋健, 瀬尾智, et al. 肝細胞癌の外科治療後再発に対するレンバチニブおよびアテゾリズマブ+ベバシズマブによる薬物療法の治療成績. 肝胆膵. 2023. 86. 3. 430-432
恵荘裕嗣, 竹田治彦, 高井淳, 高橋健, 妹尾浩. Initial experience and predictors of response to Atezolizumab plus Bevacizumab combination therapy for hepatocellular carcinoma. 肝胆膵. 2022. 84. 4
西尾太宏, 小山幸法, 小木曾聡, 楊知明, 福光剣, 石井隆道, 恵荘裕嗣, 高井淳, 高橋健, 瀬尾智, et al. Conversion surgery after lenvatinib therapy for unresectable hepatocellular carcinoma. 肝胆膵. 2022. 84. 4
恵荘裕嗣, 中野重治, 三嶋眞紗子, 井口恵里子, 竹田治彦, 高井淳, 高橋健, 妹尾浩. Atezolizumab+Bevacizumab奏効後根治的にTACEを追加した一例. 日本肝がん分子標的治療研究会プログラム・抄録集. 2021. 24th
竹田治彦, 高井淳, 恵荘裕嗣, 高橋健, 田浦康二朗, 波多野悦朗, 喜多竜一, 丸澤宏之, 藤本明洋, 妹尾浩. 多段階発癌におけるミスマッチ修復異常関連体細胞変異シグネチャーの抽出. 日本肝がん分子標的治療研究会プログラム・抄録集. 2021. 24th

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Books (6)：

PD-1/PD-L1
2020
Evolving Immunotherapy Approaches for Hepatocellular Carcinoma. Takahashi K, Marusawa H. Molecular Diagnosis and Targeting for Thoracic and Gastrointestinal Malignancy
Springer, Singapore 2018
Importance of anti-HBs antibody in hepatitis B reactivation
2013
Introduction to foreign laboratory
2013
Discoveries concerning new mechanisms for the origin and dissemination of infectious diseases Baruch Samuel Blumberg
Medical Review 2013

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Lectures and oral presentations (4)：

Prognosttic biomarkers for intrahepatoc cholangiocarcinoma: relationship between immune cell infiltration and outcomes
(2023)
In situ vaccine combining TLR9 nanoligand K3-SPG and near-infrared photoimmu notherapy evokes potent antitumor immunity
(2023)
In situ vaccine immunotherapy for gastrointestinal cancers using novel nanoparticulate TLR9 agonist K3-SPG
(DDW2020 2020)
Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection
(16th International Symposium on Hepatitis C Virus and Related Viruses 2009, NICE, France 2009)

Education (1)：

1992 - 1998 Kyoto University Faculty of Medicine

Work history (5)：

2023/04 - 現在 Kyoto University Associate professor
2022/04 - 2023/03 Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital Deputy director
2017/04 - 2022/03 Kyoto University Assistant professor
2012/04 - 2017/03 Kyoto University Assistant professor
2010/07 - 2012/03 Kyoto University

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