NAKASHIMA AYUMU

ナカシマアユム | NAKASHIMA AYUMU

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://www.hosp.yamanashi.ac.jp/departments/1442/

Research field (1)： Nephrology

Research keywords (1)： Nephrology; Dialysis therapy; Regenerative Medicine; Hypertension; Chronobiology; Atherosclerosis; CKD-MBD; Mesenchymal Stem Cells; Fibrosis; Inflammation

Research theme for competitive and other funds (27)：

2024 - 2027 Development of therapeutic methods using mesenchymal stem cell-derived extracellular small cells for acute kidney injury
2022 - 2027 elucidation of endothelial nitric oxide synthase regulation mechanism by a novel resistin-like molecule, relm beta, and its relationship to atherosclerosis
2022 - 2027 elucidation of enos regulation mechanism by a novel resistin-like molecule beta, and Its relationship to atherosclerosis
2023 - 2026 間葉系幹細胞のEpigenetic制御によるNa輸送体変化を介した降圧効果
2023 - 2026 Suppression of renal injury by extracellular vesicles from mesenchymal stem cells

2022 - 2025 内皮型NO合成酵素制御および血管内皮機能調整における時計遺伝子DEC1の役割

2021 - 2025 脂肪由来間葉系幹細胞の分化ポテンシャル予知マーカーシステムの開発

2021 - 2024 Study of treatment for suppressing renal fibrosis using mesenchymal stem cells cultured in serum-free medium.

2020 - 2023 Effect of mesenchymal stem cells on renal fibrosis: Combination with immunosuppressive therapy

2020 - 2023 Effect of DEC1 on renal fibrosis and apoptosis induced by ischemia reperfusion injury

2020 - 2023 mesenchymal stem cells with antifibrotic effect prevent impairment of cardiac function after myocardial infarction

2019 - 2022 Upregulation of mineralocorticoid receptor contributes to development of salt-sensitive hypertension after ischemic reperfusion injury in rats

2018 - 2021 Mesenchymal stem cell with anti-inflammatory effect cultured under microgravity prevents myocardial ischemia and regenerates myocardium.

2017 - 2020 Role of ROCK in stress-induced cellular senecesense on diabetes: from bench to bedside

2017 - 2020 Mesenchymal stem cell with anti-inflammatory effect cultured under microgravity prevents paraplegia after thoracic aortic repair

2017 - 2020 Supression of stress-induced senescene in kidney by transplantation of mesenchymal stem cells

2016 - 2019 Inhibition of JMJD3 attenuate renal senescense in ischemic reperfusion mice

2016 - 2018 Effect of intermittent compression in a mouse hindlimb ischemia model

2016 - 2018 TGF-beta promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA

2016 - 2018 Low-Intensity Pulsed Ultrasound Ameliorates Experimental Renal Fibrosis

2014 - 2017 Mesenchymal stem cells cultured in serum-free medium ameliorate experimental renal fibrosis.

2013 - 2015 The therapeutic effect of mesenchymal stem cells cultured under serum-free media on kidney diseases: to apply them to clinical application

2013 - 2015 iPS細胞バンクを利用した緊急被ばく対応システムの構築

2013 - 2015 The role of clock genes in non-dipper hypertension

2011 - 2013 Epidemiological study for assciation of hepatitis viral infection with mortality in patients on chronic hemodialysis

2009 - 2010 Clock genes regulate circadian variation of blood pressure via Na-K-ATPase

2007 - 2008 Effect of mesenchymal stem cell on peritoneal fibrosis in rat model

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Papers (203)：

Toshio Uchiki, Nobuyuki Hamada, Asuka Fujita, Ki-ichiro Kawano, Seiko Hirota, Makoto Maeda, Ayano Sasaki, Shogo Nagamatsu, Shinji Yoshinaga, Ayumu Nakashima, et al. Mesenchymal stem cell implantation mitigates ionizing radiation-induced vascular damage in the murine aorta. Scientific Reports. 2025
Masami Kanawa, Katsumi Fujimoto, Tania Saskianti, Ayumu Nakashima, Takeshi Kawamoto. Exploratory Analysis of Differentially Expressed Genes for Distinguishing Adipose-Derived Mesenchymal Stroma/Stem Cells from Fibroblasts. Applied Sciences. 2025
Yoshiki Tanaka, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Keisuke Morimoto, Maria Yoshida, Kensuke Sasaki, Satoshi Maeda, Go Matsuda, Takao Masaki. Overexpression of Thrombomodulin in Adipose-Derived Mesenchymal Stem Cells Reduces Thrombogenic Risk and Enhances Therapeutic Efficacy. Journal of the American Society of Nephrology. 2025
Keisuke Morimoto, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Yoshiki Tanaka, Kensuke Sasaki, Go Matsuda, Satoshi Maeda, Shigeru Miyaki, Takao Masaki. Renal protective effects of extracellular vesicle-encapsulated tumor necrosis factor-α-induced protein 6 derived from mesenchymal stem cells. Stem Cells. 2025
Takafumi Nagao, Naoki Nakao, Masataka Nagao, Hiroko Oka, Ayumu Nakashima, Mitsuhiro Uchida, Ayumu Ito, Ryota Nomura, Kazuhiro Shimamura, Akira Namera, et al. Relationship between childhood caries and social background: Regarding the novel emerged correlation between induced abortion and dental caries. Pediatric Dental Journal. 2025

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MISC (49)：

浜田信行, 川野樹一朗, 野村崇治, 古川恭治, ユソフ・ファリナ, 丸橋達也, 前田誠, 中島歩, 東幸仁. 放射線を照射した野生型マウスの大動脈に生じる血管損傷線量遷延の低減・増強効果(Sparing and enhancing effects of radiation dose protraction for vascular damage in the aorta of wild-type mice). 日本放射線影響学会大会講演要旨集. 2022. 65回. 199-199
浜田信行, 川野樹一朗, 野村崇治, 古川恭治, ユソフ・ファリナ, 丸橋達也, 前田誠, 中島歩, 東幸仁. 放射線を照射した野生型マウスの大動脈に生じる血管損傷線量遷延の低減・増強効果(Sparing and enhancing effects of radiation dose protraction for vascular damage in the aorta of wild-type mice). 日本放射線影響学会大会講演要旨集. 2022. 65回. 199-199
Kishimoto S, Kinoshita Y, Matsumoto T, Maruhashi T, Kajikawa M, Matsui S, Hashimoto H, Takaeko Y, Kihara Y, Chayama K, et al. Effects of the Dipeptidyl Peptidase 4 Inhibitor Alogliptin on Blood Pressure in Hypertensive Patients with Type 2 Diabetes Mellitus. American journal of hypertension. 2019. 32. 695-702
Maruhashi T, Kajikawa M, Kishimoto S, Matsui S, Hashimoto H, Takaeko Y, Aibara Y, Yusoff FM, Hidaka T, Chayama K, et al. Relationships Between Calcium Channel Blockers and Vascular Function Tests. American journal of hypertension. 2019. 32. 640-648
梶川正人, 丸橋達也, 日高貴之, 中野由紀子, 栗栖智, 岸本真治, 松井翔吾, 橋本東樹, 高永甲有司, Yusoff Farina Mohamad, et al. Coffee with a High Content of Chlorogenic Acids and Low Content of Hydroxyhydroquinone Ameliorates Postprandial Endothelial Dysfunction(和訳中). 日本循環器学会学術集会抄録集. 2019. 83回. OJ20-2

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Books (23)：

CKD-MBD 3rd Edition
日本メディカルセンター 2018
臨床雑誌内科
南江堂 2015
腎臓内科・泌尿器内科
科学評論社 2015
Hyaluronan-responsive genes in osteoarthritic cartilage of rat joints
The Japanese Society for Clinical Rheumatology and Related Research 2013
血液透析患者における肝炎ウイルス感染率と生命予後
2013

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Lectures and oral presentations (94)：

放射線を照射した野生型マウスの大動脈に生じる血管損傷:線量遷延の低減・増強効果
(第3回日本放射線安全管理学会・日本保健物理学会合同大会 2021)
Mesenchymal stem cells cultured in serum-free medium suppress murine bleomycin-induced pulmonary fibrosis by enhancing regulatory T cell induction
(The 25th Congress of the Asian Pacific Society of Respirology 2021)
高血圧患者の階段の使用と血管機能について
(第125回日本内科学会中国地方会 2021)
ヒストンH3K4トリメチル化酵素(MLL1/WDR5)の阻害は,老化因子p16の発現を抑制し,メチルグリオキサール(MGO)による腹膜線維化を改善する
(第27回日本腹膜透析医学会学術集会・総会 2021)
無血清培地で培養した間葉系幹細胞を用いたブレオマイシン肺線維症に対する治療効果
(第30回Pneumo Forum 2021)

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Education (2)：

2004 - 2008 Hiroshima University
1993 - 1999 Yamanashi Medical University

Professional career (1)：

博士(医学) (広島大学)

Work history (9)：

2023 - 現在 University of Yamanashi Graduate Faculty of Interdisciplinary Research Faculty of Medicine Professor
2017 - 現在 Hiroshima University Graduate School of Biomedical and Health Sciences(Medicine) Professor, Collaborative Research Laboratory
2015 - 2017 Hiroshima University Research Institute for Radiation Biology and Medicine Assistant Professor (Special Appointment)
2011 - 2015 Hiroshima University Hospital Medical Center for Translational and Clinical Research Assistant Professor (Special Appointment)
2010 - 2011 Hiroshima University Graduate School of Biomedical Sciences Assistant Professor

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Awards (6)：

2015/06 - 日本腎臓学会第58回日本腎臓学術総会会長賞
2013/07 - 第5回腎疾患と高血圧研究会研究賞
2011 - 万有財団 2011年度 Banyu Foundation Research Grant
2011 - 第15回広仁会基礎医学賞
2010/10 - 第40回日本腎臓学会西部学術大会最優秀演題賞

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Association Membership(s) (5)：

The Molecular Biology Society of Japan , The Japanese Society for Regenerative Medicine , The Japanese Society of Internal Medicine , Japanese Society of Nephrology , The Japanese Society for Dialysis Therapy

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