Kimoto Michiko

キモトミチコ | Kimoto Michiko

Affiliation and department：
Job title： Principal Research Scientist

Research field (6)： Bioorganic chemistry , Applied biochemistry , Cell biology , Molecular biology , Biomedical engineering , Molecular biochemistry

Research keywords (16)：修飾塩基 , 合成生物学 , 人工核酸 , 人工塩基対 , バイオテクノロジー , 転写 , PCR , 生体分子 , 核酸 , ライブラリー , RNA , DNA , in vitroセレクション , SELEX , 核酸アプタマー , 進化工学

Papers (83)：

Ken-Ichiro Matsunaga, Michiko Kimoto, Vanessa Weixun Lim, Hui Pen Tan, Yu Qian Wong, William Sun, Shawn Vasoo, Yee Sin Leo, Ichiro Hirao. High-affinity five/six-letter DNA aptamers with superior specificity enabling the detection of dengue NS1 protein variants beyond the serotype identification. Nucleic acids research. 2021. 49. 20. 11407-11424
Samira Husen Alamudi, Michiko Kimoto, Ichiro Hirao. Uptake mechanisms of cell-internalizing nucleic acid aptamers for applications as pharmacological agents. RSC medicinal chemistry. 2021. 12. 10. 1640-1649
Ken-Ichiro Matsunaga, Michiko Kimoto, Vanessa Weixun Lim, Tun-Linn Thein, Shawn Vasoo, Yee-Sin Leo, William Sun, Ichiro Hirao. Competitive ELISA for a serologic test to detect dengue serotype-specific anti-NS1 IgGs using high-affinity UB-DNA aptamers. Scientific reports. 2021. 11. 1. 18000-18000
Michiko Kimoto, Ichiro Hirao. Genetic alphabet expansion technology by creating unnatural base pairs. CHEMICAL SOCIETY REVIEWS. 2020. 49. 21. 7602-7626
Michiko Kimoto, Si Hui Gabriella Soh, Hui Pen Tan, Itaru Okamoto, Ichiro Hirao. Cognate base-pair selectivity of hydrophobic unnatural bases in DNA ligation by T4 DNA ligase. BIOPOLYMERS. 2020. 112. 1. e23407

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MISC (1)：

T Ohtsuki, M Kimoto, M Ishikawa, T Mitsui, Hirao, I, S Yokoyama. Unnatural base pairs for specific transcription. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001. 98. 9. 4922-4925

Work history (7)：

2019/04 - 現在 Institute of Bioengineering and Nanotechnology, A*STAR Principal Research Scientist
2015/11 - 2019/03 Institute of Bioengineering and Nanotechnology, A*STAR Senior Research Scientist
2013/04 - 2015/10 RIKEN Senior Research Scientist
2006/04 - 2015/09 Chiba Institute of Technology
2006/04 - 2013/03 RIKEN Research Scieintist

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