Murata Yoji

ムラタヨウジ | Murata Yoji

Affiliation and department：
Job title： Associate Professor

Research field (1)： Medical biochemistry

Research theme for competitive and other funds (12)：

2022 - 2025 がん微小環境における細胞間シグナルによる腫瘍免疫制御
2019 - 2022 Molecular mechanisms underlying an immune evasion by cancer cells via cell-to-cell signaling
2016 - 2019 腸上皮細胞特異的チロシンホスファターゼによる腸管免疫制御機構の解析
2014 - 2017 Molecular basis of the CD47-SIRP alpha signaling system in the regulation of physiological function
2013 - 2016 消化管粘膜上皮細胞特異的なチロシンホスファターゼを介した腸管免疫制御と病態

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Papers (69)：

Yasuyuki Saito, Rie Iida-Norita, Tania Afroj, Alaa Refaat, Daisuke Hazama, Satomi Komori, Shinya Ohata, Tomoko Takai, Okechi S. Oduori, Takenori Kotani, et al. Preclinical evaluation of the efficacy of an antibody to human SIRPα for cancer immunotherapy in humanized mouse models. Frontiers in Immunology. 2023. 14
Michiko Itoh, Atsushi Tamura, Sayaka Kanai, Miyako Tanaka, Yohei Kanamori, Ibuki Shirakawa, Ayaka Ito, Yasuyoshi Oka, Isao Hidaka, Taro Takami, et al. Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH. The Journal of experimental medicine. 2023. 220. 11
Satomi Komori, Yasuyuki Saito, Taichi Nishimura, Datu Respatika, Hiromi Endoh, Hiroki Yoshida, Risa Sugihara, Rie Iida-Norita, Tania Afroj, Tomoko Takai, et al. CD47 promotes peripheral T cell survival by preventing dendritic cell-mediated T cell necroptosis. Proceedings of the National Academy of Sciences. 2023. 120. 33
小谷武徳, 村田陽二, 齊藤泰之, 的崎尚. 【新しいがん免疫療法研究の展開と臨床応用】自然免疫制御を介したがん免疫療法の進展 CD47-SIRPα経路の制御によるがん免疫療法. 腫瘍内科. 2023. 31. 3. 327-333
Okamoto T, Murata Y, Hasegawa D, Yoshida M, Tanaka D, Ueda T, Hazama D, Oduori OS, Komori S, Takai T, et al. Targeting of SIRPα as a potential therapy for Langerhans cell histiocytosis. Cancer science. 2023

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MISC (71)：

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Books (1)：

Lectures and oral presentations (160)：

Antibodies to SIRPα/SIRPβ as a potential tool for immunotherapy of bladder cancer
(14th International Conference on Protein Phosphatase 2020)
Blockade of the CD47-SIRPα interaction by SIRPα-binding macrocyclic peptides as a potential cancer immunotherapy
(14th International Conference on Protein Phosphatase 2020)
Roles of Shp2-Ras, Src family kinases, and mTOR signaling in intestinal epithelial homeostasis
(14th International Conference on Protein Phosphatase 2020)
Role of CD47 on the regulation of peripheral T cell survival by dendritic cells
(14th International Conference on Protein Phosphatase 2020)
A novel humanized mouse model for assessing human macrophage-targeted cancer immunotherapy in vivo
(14th International Conference on Protein Phosphatase 2020)

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Education (1)：

Professional career (2)：

Awards (1)：

2016/10 - 神戸大学平成27年度神戸大学医学部優秀学術論文賞 Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium

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