Tsuru Michiyo

ツルミチヨ | Tsuru Michiyo

Affiliation and department：
Job title： Research Institute Director
Homepage URL (1)： http://www.med.kurume-u.ac.jp/med/sgc/index.html

Research field (9)： Statistical science , Other , Tumor diagnostics and therapeutics , Biophysics , Functional biochemistry , Sports science , Tumor biology , Healthcare management, medical sociology , Orthopedics

Research keywords (4)： Unmet Medical Needs , Preparation of mesenchymal stem cell-derived ligament tissue, Tommy John surgery transplantation , Drugs for early detection and prevention of cancer metastasis , Ossification of the posterior longitudinal ligament (OPLL) drug development, OPLL model mouse

Research theme for competitive and other funds (21)：

2012 - 2017 OPLL model mouse and mechanisms-de-ubiquitination leads to a posterior longitudinal ligament ossification breakthrough in proteomics
2012 - 2016 The world's first, ligament ossification blocker pharmaceutical the development by stem cell derived ligament tissues making success
2010 - 2015 Phenotypic analysis of conventional knockout mice lacking the protein responsible for ossification of the posterior longitudinal ligament
2009 - 2014 Discovery and the elucidation of a mechanism of an incurable disease and ossification-of-posterior-longitudinal-ligament specific protein
2013 - 後縦靭帯骨化症の疾患特異的タンパク質による創薬研究

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Papers (22)：

Michiyo Tsuru, Takayoshi Oosio, Teruyo Higashi, Kensei Nagata, Kanichiro Wada, Yasuyuki Ishibashi. Association between periodontitis and ossification of the posterior longitudinal ligament: a case report. Journal of Medical Case Reports. 2022. 16. 1. 236-236
Tsuru Michiyo. 15th Lily Research Grant Program (Bone Area Research) Results Report. 15th Lily Research Grant Program (Bone Area Research) Results Report. 2021
Michiyo Tsuru, Atsushi Ono, Hideaki Umeyama, Masahiro Takeuchi, Kensei Nagata. Ubiquitin-dependent proteolysis of CXCL7 leads to posterior longitudinal ligament ossification. PLoS ONE. 2018. 13. 5. e0196204
Michiyo Tsuru, Michio Sata, Maki Tanaka, Hideaki Umeyama, Yoshio Kodera, Mieko Shiwa, Norikazu Aoyagi, Kaori Yasuda, Kei Matsuoka, Takaaki Fukuda, et al. Retrospective Proteomic Analysis of a Novel, Cancer Metastasis-Promoting RGD-Containing Peptide. TRANSLATIONAL ONCOLOGY. 2017. 10. 6. 998-1007
津留美智代, 梅山秀明, 竹内正弘, 松本博行, 永田見生. 整形外科難治性疾患に対する基礎研究の成果後縦靱帯骨化症原因タンパク質の発見と創薬研究. 日本整形外科学会雑誌. 2016. 90. 8. S1664-S1664

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MISC (100)：

津留美智代, 松本博行, 永田見生. 後縦靱帯骨化症モデルマウスによる靱帯骨化メカニズムの解明. 日本骨代謝学会学術集会プログラム抄録集. 2019. 37回. 196-196
津留美智代. 20190521. Japan Society of Clinical Proteogenomics (JSCP). 2019. 2019. 0. 9-9
津留美智代. 20190521. Japan Society of Clinical Proteogenomics (JSCP). 2019. 2019. 0. 13-13
Michiyo Tsuru. http://www.jsbmr.jp/1st_author/328_mtsuru.html. http://www.jsbmr.jp/1st_author/328_mtsuru.html. 2018
津留美智代, 小野睦, 内田研造, 戸山芳昭, 永田見生. ゲノムビッグデータとバイオインフォマティクス新たな創薬へ後縦靱帯骨化症モデルマウスの作製による治療製剤への開発研究. 日本整形外科学会雑誌. 2015. 89. 8. S1530-S1530

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Patents (13)：

Spinal ligament ossification model non-human animal, diabetes model non-human animal, spinal ligament ossification model cell, screening method, detection method of spinal ligament ossification disease cell, spinal ligament ossification diagnosis kit, and spinal ligament Osteosis treatment agent
Cancer metastasis marker and diagnosis method of cancer metastasis using cancer metastasis's peptids.
Method for producing parallel fibrous connective tissue
癌転移マーカー及びそれを用いた癌転移の診断方法
平行線維性結合組織の製造方法

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Books (5)：

AGEs and Aging
Medical Review 2012 ISBN:9784779210051
最新基礎科学腰椎椎間板再生遺伝子の発見
医学書院 2010
Forefront of disease proteomics
2004
トランスレーショナル・リサーチの体制づくりと人材育成.
羊土社Bioベンチャー 2004
Advances in Spinal Fusion: Molecular Science, BioMechanics, and Clinical Management
Cambridge Scientific, Inc. c/o M&N Toscano 2003 ISBN:0824743105

Lectures and oral presentations (57)：

Elucidation of ligament ossification mechanism using posterior longitudinal ligament ossification model mouse
(The 37th Annual Meeting of the Japanese Society for Bone Metabolism 2019)
Discovery of the cause protein of the ossification of posterior longitudinal ligament; OPLL (public welfare labor designation intractable disease) and proof elucidation with the model mouse
(The 15th Annual Meeting of Japan Society for Clinical Proteogenomics 2019)
Retrospective proteomic analysis of a novel, cancer metastasis-promoting RGD-containing peptide
(The 15th Annual Meeting of Japan Society for Clinical Proteogenomics 2019)
Statistical search method for disease-specific proteins
(Togo - Japan sponsored by the Japan Science and Technology Agency (JST), Ministry of Education, Culture, Sports, Science and Technology and the Ministry of Health, Labor and Welfare Co-organized Research Results Fruitful Report 2016)
整形外科難治性疾患に対する基礎研究の成果後縦靱帯骨化症原因タンパク質の発見と創薬研究
(日本整形外科学会雑誌 2016)

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Works (5)：

Rheumatoid arthritis clinical trial of hesperidin,
Ezaki Glico Co 2002 -
OP-1 Strut Allograft Healing to the Femur with recombinant Human
Nippon Striker Co., Lt 2002 -
FOY Clinical Trial
Ono Pharmaceutical Co, L 1990 - 1991
Translational research
Michiyo Tsuru
proof of concept, Non-clinical study
Michiyo Tsuru, JRA

Education (3)：

2004 - 2006 Master of Biostatistics, Kurume University School of Medicine
2003 - 2003 Kitasato University doctor of life sciences
1983 - 1987 Kitasato University

Professional career (3)：

Ph.D. (Life Science Dr)
修士(医科学) (久留米大学)
学士(保健衛生学) (北里大学)

Work history (10)：

2026/01 - 現在 Unmet medical needs, Drug development, Intractable diseases, Malignant tumors, Stem cell regenerative medicine, Transplantation, Research Institute Director (PhD) Research Institute Director
2022/08 - 現在 Unmet Medical Needs 新薬開発 Drug development, intractable diseases, malignant tumors, stem cell regenerative medicine transplantation Research Institute Director
2014/04 - 2019/12 Kurume University
2008 - 2012 Kurume University School of Medicine
2003/12 - 2008/03 Kurume University Biostatistics Center

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Awards (4)：

2018/11 - Japan Osteoporosis Foundation Clinical study on osteoporosis
2006 - Research Award, AstraZeneca Research Grant. Research Award, AstraZeneca Research Grant. New preventative strategy for human bone metastases targeting a specific novel protein.
2005 - Research Award, Lilly Fellowship and Research Grant Program for Bone & Mineral Research.
2002/05 - Research Award, Second European Conference on Bone Morphogenetic Proteins. Research Award, Second European Conference on Bone Morphogenetic Proteins. Gene Therapy using in vivo Electroporation of Human BMP-2 Gene in Klotho mice.

Association Membership(s) (8)：

JACCRO , THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE , JAPANESE SOCIETY OF GASTROENTEROLOGY , THE JAPANESE CANCER ASSOCIATION , JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH , THE JAPANESE ORTHOPAEDIC ASSOCIATION , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , Japan Society for Clinical Proteogenomics

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