Rchr
J-GLOBAL ID:201301087868842570   Update date: Dec. 01, 2021

Tsuru Michiyo

ツル ミチヨ | Tsuru Michiyo
Affiliation and department:
Job title: Lecturer
Other affiliations (1):
Homepage URL  (1): http://www.med.kurume-u.ac.jp/med/sgc/index.html
Research field  (9): Statistical science ,  Other ,  Tumor diagnostics and therapeutics ,  Biophysics ,  Functional biochemistry ,  Sports science ,  Tumor biology ,  Healthcare management, medical sociology ,  Orthopedics
Research keywords  (34): Drug Delivery System, ,  Drug Delivery System, DDS ,  電子顕微鏡 ,  nonclinical test ,  Proof of Concept: POC ,  浸潤・転移 ,  Cancer Epithelial-Mesenchymal Transition ,  Ubiquitin ,  ligament ,  Mesenchymal stem cells ,  ossification of posterior longitudinal ligament ,  Protein modification ,  予防 ,  創薬 ,  タンパク質 ,  アミノ酸 ,  転移 ,  がん ,  立体構造 ,  骨転移 ,  first in human: FIH ,  NMR解析 ,  アンタゴニスト ,  機能性RNA ,  miRNA ,  micro RNA ,  がん遺伝子 ,  質量分析 ,  骨・軟部腫瘍学 ,  がん転移 ,  橋渡し研究 ,  proteomics ,  バイオマーカー ,  椎間板ヘルニア
Research theme for competitive and other funds  (21):
  • 2012 - 2017 OPLL model mouse and mechanisms-de-ubiquitination leads to a posterior longitudinal ligament ossification breakthrough in proteomics
  • 2012 - 2016 The world's first, ligament ossification blocker pharmaceutical the development by stem cell derived ligament tissues making success
  • 2010 - 2015 Phenotypic analysis of conventional knockout mice lacking the protein responsible for ossification of the posterior longitudinal ligament
  • 2009 - 2014 Discovery and the elucidation of a mechanism of an incurable disease and ossification-of-posterior-longitudinal-ligament specific protein
  • 2013 - 後縦靭帯骨化症の疾患特異的タンパク質による創薬研究
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Papers (22):
MISC (100):
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Patents (13):
Books (5):
  • AGEs and Aging
    Medical Review 2012 ISBN:9784779210051
  • 最新基礎科学 腰椎椎間板再生遺伝子の発見
    医学書院 2010
  • Forefront of disease proteomics
    2004
  • トランスレーショナル・リサーチの体制づくりと人材育成.
    羊土社Bioベンチャー 2004
  • Advances in Spinal Fusion: Molecular Science, BioMechanics, and Clinical Management
    Cambridge Scientific, Inc. c/o M&N Toscano 2003 ISBN:0824743105
Lectures and oral presentations  (57):
  • Elucidation of ligament ossification mechanism using posterior longitudinal ligament ossification model mouse
    (The 37th Annual Meeting of the Japanese Society for Bone Metabolism 2019)
  • Discovery of the cause protein of the ossification of posterior longitudinal ligament; OPLL (public welfare labor designation intractable disease) and proof elucidation with the model mouse
    (The 15th Annual Meeting of Japan Society for Clinical Proteogenomics 2019)
  • Retrospective proteomic analysis of a novel, cancer metastasis-promoting RGD-containing peptide
    (The 15th Annual Meeting of Japan Society for Clinical Proteogenomics 2019)
  • Statistical search method for disease-specific proteins
    (Togo - Japan sponsored by the Japan Science and Technology Agency (JST), Ministry of Education, Culture, Sports, Science and Technology and the Ministry of Health, Labor and Welfare Co-organized Research Results Fruitful Report 2016)
  • 整形外科難治性疾患に対する基礎研究の成果 後縦靱帯骨化症原因タンパク質の発見と創薬研究
    (日本整形外科学会雑誌 2016)
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Works (5):
  • Rheumatoid arthritis clinical trial of hesperidin,
    Ezaki Glico Co 2002 -
  • OP-1 Strut Allograft Healing to the Femur with recombinant Human
    Nippon Striker Co., Lt 2002 -
  • FOY Clinical Trial
    Ono Pharmaceutical Co, L 1990 - 1991
  • Translational research
    Michiyo Tsuru
  • proof of concept, Non-clinical study
    Michiyo Tsuru, JRA
Education (3):
  • 2004 - 2006 Master of Biostatistics, Kurume University School of Medicine
  • 2003 - 2003 Kitasato University doctor of life sciences
  • 1983 - 1987 Kitasato University
Professional career (3):
  • Ph.D. (Life Science Dr)
  • 修士(医科学) (久留米大学)
  • 学士(保健衛生学) (北里大学)
Work history (8):
  • 2014/04 - 2019/12 Kurume University
  • 2008 - 2012 Kurume University School of Medicine
  • 2003/12 - 2008/03 Kurume University Biostatistics Center
  • 2003/12 - 2008/03 Ministry of Education,Culture,Sports,Science and Technology
  • 2003/07 - 2003/11 Kurume University School of Medicine
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Awards (4):
  • 2018/11 - Japan Osteoporosis Foundation Clinical study on osteoporosis
  • 2006 - Research Award, AstraZeneca Research Grant. Research Award, AstraZeneca Research Grant. New preventative strategy for human bone metastases targeting a specific novel protein.
  • 2005 - Research Award, Lilly Felloeship and Research Grant Program for Bone & Mineral Research. Research Award, Lilly Felloeship and Research Grant Program for Bone & Mineral Research.
  • 2002/05 - Research Award, Second European Conference on Bone Morphogenetic Proteins. Research Award, Second European Conference on Bone Morphogenetic Proteins. Gene Therapy using in vivo Electroporation of Human BMP-2 Gene in Klotho mice.
Association Membership(s) (8):
JACCRO ,  THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE ,  JAPANESE SOCIETY OF GASTROENTEROLOGY ,  THE JAPANESE CANCER ASSOCIATION ,  JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH ,  THE JAPANESE ORTHOPAEDIC ASSOCIATION ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  Japan Society for Clinical Proteogenomics
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