Rchr
J-GLOBAL ID：201301093120088199   Update date: Sep. 11, 2024

Murata Takuya

ムラタ タクヤ | Murata Takuya
Research field  (3)： Genetics ,  Developmental biology ,  Laboratory animal science
Research keywords  (7)： Wnt Signal ,  ENU ,  Mouse Genetics ,  Reverse Genetics ,  Disease Model ,  Mutant Mouse ,  Knockout Mouse
Research theme for competitive and other funds  (5)：
  • 2013 - 2015 Developing disease model mice in "post-knockout era" by allelic series of point mutations.
  • 2012 - 2013 Versatility vs Specificity on Wnt/ß-catenin signaling cascade ~From C429S amino-acid-substitution mutation mice~
  • 2009 - 2012 High-throughput development of disease model mice by using next-generation technologies.
  • 2001 - 2004 前脳形成の分子機構
  • 1996 - 2000 Genetic Analysis of head development in vertebrates
Papers (17)：
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MISC (11)：
  • Shigeru Makino, Olena Zhulyn, Takuya Murata, Ryutaro Fukumura, Yuichi Ishitsuka, Hayato Kotaki, Chi-Chung Hui, Yoichi Gondo. Regulation of Gli transcription factors based on Sufu mutations in the mouse. GENES & GENETIC SYSTEMS. 2014. 89. 6. 333-333
  • Shigeru Makino, Takuya Murata, Ryutaro Fukumura, Yuichi Ishitsuka, Hayato Kotaki, Yoichi Gondo. Analysis of mouse Hedgehog signal transduction with compound heterozygotes among multiple point mutations in Sufu. GENES & GENETIC SYSTEMS. 2013. 88. 6. 364-364
  • Shigeru Makino, Takuya Murata, Ryutaro Fukumura, Yuichi Ishitsuka, Hayato Kotaki, Yoichi Gondo. Analysis of an ENU-induced mutation in Sufu identified a new regulatory mechanism of the Gli transcription factors. GENES & GENETIC SYSTEMS. 2011. 86. 6. 423-423
  • Takuya Murata, Yuichi Ishitsuka, Shigeru Makino, Ryutaro Fukumura, Yuji Nakai, Hayato Kotaki, Hideki Kaneda, Shigeharu Wakana, Gen Yamada, Yoichi Gondo. Elucidating the beta-catenin gene function from new sterile model mice. GENES & GENETIC SYSTEMS. 2011. 86. 6. 416-416
  • Yoichi Gondo, Ryutaro Fukumura, Takuya Murata, Shigeru Makino. Mutant mouse library now elucidates the genome function bridging monogenic and polygenic traits. GENES & GENETIC SYSTEMS. 2011. 86. 6. 398-398
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Lectures and oral presentations  (21)：
  • New Infertile Mouse Model for Mayer-Rokitansky-Küster-Hauser syndrome (MRKH)
    (IFFS/JSRM International Meeting 2015 2015)
  • The mouse strain possessing the Cys429Ser base substitution of the β-catenin gene showed spatiotemporal sustainment of the canonical Wnt/ β-catenin signal during organogeneses of internal genitaria
    (EMBO Workshop on Wnt signalling 2014)
  • Caudal Wolffian duct with abnormally sustained Wnt/ß-catenin signal prevents upper vaginal elongation, which causes vaginal atresia in the -catenin C429S mouse.
    (Annual meeting of the Society for the Study of Reproduction 2014 2014)
  • The C429S mutation of the CTNNB1, which encodes essential component of the canonical Wnt signaling, caused the infertilities with internal genital malformations in the mouse.
    (Human Genome Meeting 2014 2014)
  • The β-catenin^C429S mice cause infertility with spatiotemporally sustained Wnt signal in internal genitalia
    (Seminar in LARGE, CDB, RIKEN 2014)
ｍore...
Education (2)：
  • 1993 - 1998 Kyoto University Graduate School of Science
  • 1989 - 1993 Kyoto University Faculty of Science
Professional career (1)：
  • PhD (Kyoto University)
Work history (7)：
  • 2019/05 - 2022/09 京都大学 学術研究支援室
  • 2018/11 - 2019/05 京都産業大学 研究機構
  • 2015/02 - 2018/10 神戸大学 学術研究推進機構
  • 2007/04 - 2015/01 RIKEN BRC Research and Development Scientist
  • 2005/04 - 2007/03 RIKEN GSC Research Scientist
Show all
Awards (4)：
  • 2014/06 - The Society for the Study of Reproduction International Award for Best Abstract by Region
  • 2011/07 - Society for the Study of Reproduction Lalor Foundation Merit Awards An Amino-Acid-Substitution Mutation of the Beta-Catenin Gene Caused Transformation of Caudal Wollfian Duct to Seminal Vesicle of Males and Vaginal Atresia of Females in the Mouse.
  • 2010/10 - International Mammalian Genome Conference Best Poster Award New sterile model mouse from RIKEN ENU-based gene-driven mutagenesis
  • 2010/09 - The Genetic Society of Japan Best Paper Award
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