Kuroki Kimiko

クロキキミコ | Kuroki Kimiko

Affiliation and department：
Job title：准教授
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/90553313.ja.html

Research field (7)： Genomics , Pharmaceuticals - analytical and physicochemistry , Immunology , Medical biochemistry , Biophysics , Functional biochemistry , Structural biochemistry

Research keywords (16)：ウイルスペプチド , 抗体医薬品 , 構造解析 , 分子免疫学 , バイオ医薬品 , 遺伝子多型産物 , HIV Nef , HIV-2 , 免疫チェックポイント , LILR , KIR , 免疫制御 , HLA , 表面プラズモン共鳴法 , 細胞表面受容体 , 蛋白質間相互作用

Research theme for competitive and other funds (8)：

2022 - 2025 免疫抑制分子HLA-Gアイソフォームを特異的に機能阻害する腫瘍治療抗体医薬品開発
2018 - 2021 Molecular recognition of immune inhibitory receptor, LILRB2, with HLA-G2 and various ligands
2013 - 2015 強直性脊椎炎病因蛋白質HLA-B27の受容体LILRB2を介した発症機構の解明
2013 - 2015 Structural analysis of HLA-G6 isoform bound to LILRB2 receptor
2011 - 2013 強直性脊椎炎病因蛋白質HLA-B27ホモ二量体の立体構造解析

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Papers (69)：

Takayuki Chikata, Wayne Paes, Nozomi Kuse, Thomas Partridge, Hiroyuki Gatanaga, Yu Zhang, Kimiko Kuroki, Katsumi Maenaka, Nicola Ternette, Shinichi Oka, et al. Impact of Micropolymorphism Outside the Peptide Binding Groove in the Clinically Relevant Allele HLA-C*14 on T Cell Responses in HIV-1 Infection. Journal of virology. 2022. 96. 10. e0043222
Kimiko Kuroki, Hideo Fukuhara, Takashi Tadokoro, Katsumi Maenaka. Low-Cost Cell-Surface-Mimic Analysis of Ligand Interactions of Biotinylated Immune Receptors Using Surface Plasmon Resonance. Methods in molecular biology (Clifton, N.J.). 2022. 2421. 21-35
谷川雄哉, 金村進吾, 伊藤大, 林雨曦, 松崎元紀, 黒木喜美子, 山口宏, 前仲勝実, 李映昊, 稲葉謙次, et al. カルシウムイオンによるERp57-CNX複合体の構造機能調節. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [3T14m-245)]
Yuya Tanikawa, Shingo Kanemura, Dai Ito, Yuxi Lin, Motonori Matsusaki, Kimiko Kuroki, Hiroshi Yamaguchi, Katsumi Maenaka, Young-Ho Lee, Kenji Inaba, et al. Ca2+ Regulates ERp57-Calnexin Complex Formation. Molecules. 2021. 26. 10. 2853-2853
Structural and Functional Basis for LILRB Immune Checkpoint Receptor Recognition of HLA-G isoforms. 2020. 38. 35-36

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MISC (133)：

黒木喜美子. 【免疫系多重遺伝子ファミリー多様性と疾患】免疫系多重遺伝子ファミリー分子LILRBの構造解析と疾患. 炎症と免疫. 2022. 30. 5. 390-393
渡邊紘士, 黒木喜美子, 前仲勝実. 免疫抑制性タンパク質HLA-G2の新規受容体探索と結合親和性評価. 日本薬学会年会要旨集. 2022. 142年会. 26L-pm03S
黒木喜美子. 物理系薬学部会シンポジウム~若い力で推進する物理系薬学~ 免疫抑制タンパク質HLA-Gの機能・構造解析. 日本薬学会年会要旨集. 2022. 142年会. S01-4
渡邊紘士, 黒木喜美子, 前仲勝実. Identification and characterization of novel receptors for HLA-G2. 日本薬学会年会要旨集(Web). 2022. 142年会. 26L-pm03S
渡邊紘士, 黒木喜美子, 前仲勝実. 免疫系受容体の弱く速い結合を介したリガンド認識機構-Ligand recognition mechanisms by immune system receptors via weak and fast binding-特集物質共生の観点からDDSを考える. Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System / 日本DDS学会編. 2022. 37. 2. 112-121

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Patents (11)：

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Education (2)：

- 2004 The University of Tokyo Graduate School of Medicine International Health
- 1999 Tokyo University of Science Faculty of Science and Technology Applied Biological Science

Professional career (1)：

博士(保健学) (東京大学大学院)

Work history (6)：

2018/04 - 現在北海道大学薬学研究院
2010/07 - 2018/03 Hokkaido University Faculty of Pharmaceutical Sciences
2010/04 - 2010/06 Hokkaido University Faculty of Pharmaceutical Sciences
2008/04 - 2010/03 Kyushu University Medical Institute of Bioregulation
2004/04 - 2008/03 Kyushu University Medical Institute of Bioregulation

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Association Membership(s) (6)：

JAPANESE SOCIETY FOR HISTOCOMPATIBILITY AND IMMUNOGENETICS , THE JAPANESE SOCIETY FOR IMMUNOLOGY , JAPAN COLLEGE OF RHEUMATOLOGY , THE JAPANESE BIOCHEMICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN

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