Art

J-GLOBAL ID：201302201116310619   Reference number：13A1938071

Properties of leukemic stem cells and treatment strategy for the cure of chronic myelogenous leukemia

慢性骨髄性白血病幹細胞の性状と治癒に向けての治療戦略

Author (1)： MINAMI YOSUKE (名古屋大学大学院医学系研究科(現 神戸大学医学部附属病院))
Material： 臨床血液  (Japanese Journal of Clinical Hematology)
Volume： 54  Issue： 6  Page： 552-558 (J-STAGE)  Publication year： 2013 
JST Material Number： Z0688A  ISSN： 0485-1439  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： human(primates) ,...
Semi thesaurus term： BCR-ABL gene ,...

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JST classification (2)： Blood cell tumors(=neoplasms)  (GK04000M) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (1)： Imatinib

Reference (27)：

• MAHON, FX. Intergroupe Francais des Leucemies Myeloides Chroniques. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years : the prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol. 2010, 11, 1029-1035
• CORBIN, AS. Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J Clin Invest. 2011, 121, 396-409
• GRAHAM, SM. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002, 99, 319-325
• STUART, SA. The CML stem cell : evolution of the progenitor. Cell Cycle. 2009, 8, 1338-1343
• O'HARE, T. Pushing the limits of targeted therapy in chronic myeloid leukaemia. Nat Rev Cancer. 2012, 12, 513-526

Terms in the title (5)： 慢性骨髄性白血病 ,  幹細胞 ,  性状 ,  治癒 ,  治療戦略