Art

J-GLOBAL ID：201302202333575201   Reference number：13A0316993

The Dynamic Process of β₂-Adrenergic Receptor Activation

β₂アドレナリン作動性受容体活性化の動的プロセス

Author (16)： NYGAARD Rie (Dep. of Molecular and Cellular Physiology, Stanford Univ. School of Medicine, Stanford, CA 94305, USA) ,  ZOU Yaozhong (Dep. of Molecular and Cellular Physiology, Stanford Univ. School of Medicine, Stanford, CA 94305, USA) ,  DROR Ron O. (D.E. Shaw Res., New York, NY 10036, USA) ,  MILDORF Thomas J. (D.E. Shaw Res., New York, NY 10036, USA) ,  ARLOW Daniel H. (D.E. Shaw Res., New York, NY 10036, USA) ,  MANGLIK Aashish (Dep. of Molecular and Cellular Physiology, Stanford Univ. School of Medicine, Stanford, CA 94305, USA) ,  PAN Albert C. (D.E. Shaw Res., New York, NY 10036, USA) ,  LIU Corey W. (Stanford Magnetic Resonance Lab., Stanford Univ. School of Medicine, Stanford, CA 94305, USA) ,  FUNG Juan Jose (Dep. of Molecular and Cellular Physiology, Stanford Univ. School of Medicine, Stanford, CA 94305, USA) ,  BOKOCH Michael P. (Dep. of Molecular and Cellular Physiology, Stanford Univ. School of Medicine, Stanford, CA 94305, USA) ,  THIAN Foon Sun (Dep. of Molecular and Cellular Physiology, Stanford Univ. School of Medicine, Stanford, CA 94305, USA) ,  KOBILKA Tong Sun (Dep. of Molecular and Cellular Physiology, Stanford Univ. School of Medicine, Stanford, CA 94305, USA) ,  SHAW David E. (D.E. Shaw Res., New York, NY 10036, USA) ,  MUELLER Luciano (Bristol-Myers Squibb Pharmaceutical Res. Inst., Princeton, NJ 08543, USA) ,  PROSSER R. Scott (Dep. of Chemistry, Univ. of Toronto, UTM, Mississauga, Ontario L5L 1C6, CAN) ,  KOBILKA Brian K. (Dep. of Molecular and Cellular Physiology, Stanford Univ. School of Medicine, Stanford, CA 94305, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 152  Issue： 3  Page： 532-542  Publication year： Jan. 31, 2013 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *steric conformation ,  *Computer Simulation ,  NMR ,  binding and coupling ,  *beta-2 adrenergic receptor ,  amino acid residue ,  conformational transition ,  intermolecular interaction ,  membrane receptor ,  GTP binding protein ,  base pair substitution ,  Protein Engineering ,  beta adrenergic antagonist ,  nitrogen heterocyclic compound ,  phenol ether ,  polynuclear aromatic compound ,  aminoalcohol ,  secondary amine ,  secondary alcohol ,  Amino Acid Substitution ,  methionine residue ,  ligand binding ,  protein-protein interaction ,  *Protein Conformation ,  *Molecular Dynamics Simulation ,  G protein-coupled receptor ,  *computer application ,  *utilization
Semi thesaurus term： GPCR ,  HSQC spectrum

JST classification (2)： Molecular structure  (EB03020Y) ,  Molecular and genetic information processing  (JE15040B)

Substance index (2)： BI-167107 ,  Carazolol

Terms in the title (3)： アドレナリン作動性受容体 ,  活性化 ,  動的プロセス