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J-GLOBAL ID：201302203403063722   Reference number：13A1028693

Malt1-Induced Cleavage of Regnase-1 in CD4⁺ Helper T Cells Regulates Immune Activation

CD4⁺ヘルパーT細胞におけるRegnase-1のMalt1誘導性切断は免疫活性化を制御する

Author (22)： UEHATA Takuya (Lab. of Host Defense, Osaka Univ., 3-1 Yamada-oka, Suita, Osaka 565-0871, JPN) ,  UEHATA Takuya (Dep. of Geriatric Medicine and Nephrology, Osaka Univ. Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka ...) ,  IWASAKI Hidenori (Lab. of Host Defense, Osaka Univ., 3-1 Yamada-oka, Suita, Osaka 565-0871, JPN) ,  IWASAKI Hidenori (Central Pharmaceutical Res. Inst., Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, JPN) ,  VANDENBON Alexis (Lab. of Systems Immunology, WPI Immunology Frontier Res. Center (IFReC), Osaka Univ., 3-1 Yamada-oka, Suita, Osaka ...) ,  MATSUSHITA Kazufumi (Lab. of Host Defense, Osaka Univ., 3-1 Yamada-oka, Suita, Osaka 565-0871, JPN) ,  HERNANDEZ-CUELLAR Eduardo (Lab. of Host Defense, Osaka Univ., 3-1 Yamada-oka, Suita, Osaka 565-0871, JPN) ,  KUNIYOSHI Kanako (Lab. of Host Defense, Osaka Univ., 3-1 Yamada-oka, Suita, Osaka 565-0871, JPN) ,  KUNIYOSHI Kanako (Res. Inst. for Microbial Diseases, Osaka Univ., 3-1 Yamada-oka, Suita, Osaka 565-0871, JPN) ,  SATOH Takashi (Lab. of Host Defense, Osaka Univ., 3-1 Yamada-oka, Suita, Osaka 565-0871, JPN) ,  SATOH Takashi (Res. Inst. for Microbial Diseases, Osaka Univ., 3-1 Yamada-oka, Suita, Osaka 565-0871, JPN) ,  MINO Takashi (Lab. of Infection and Prevention, Inst. for Virus Res., Kyoto Univ., 53 Shogoin Kawara-cho, Sakyo-ku, Kyoto 606-8507 ...) ,  SUZUKI Yutaka (Lab. of Functional Genomics, Dep. of Medical Genome Sciences, Graduate School of Frontier Sciences, The Univ. of ...) ,  STANDLEY Daron M. (Lab. of Systems Immunology, WPI Immunology Frontier Res. Center (IFReC), Osaka Univ., 3-1 Yamada-oka, Suita, Osaka ...) ,  TSUJIMURA Tohru (Dep. of Pathology, Hyogo Coll. of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, JPN) ,  RAKUGI Hiromi (Dep. of Geriatric Medicine and Nephrology, Osaka Univ. Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka ...) ,  ISAKA Yoshitaka (Dep. of Geriatric Medicine and Nephrology, Osaka Univ. Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka ...) ,  TAKEUCHI Osamu (Lab. of Host Defense, Osaka Univ., 3-1 Yamada-oka, Suita, Osaka 565-0871, JPN) ,  TAKEUCHI Osamu (Lab. of Infection and Prevention, Inst. for Virus Res., Kyoto Univ., 53 Shogoin Kawara-cho, Sakyo-ku, Kyoto 606-8507 ...) ,  TAKEUCHI Osamu (CREST, JST, 53 Shogoin Kawara-cho, Sakyo-ku, Kyoto 606-8507, JPN) ,  AKIRA Shizuo (Lab. of Host Defense, Osaka Univ., 3-1 Yamada-oka, Suita, Osaka 565-0871, JPN) ,  AKIRA Shizuo (Res. Inst. for Microbial Diseases, Osaka Univ., 3-1 Yamada-oka, Suita, Osaka 565-0871, JPN)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 153  Issue： 5  Page： 1036-1049  Publication year： May. 23, 2013 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *helper T cell ,  *Proteins ,  *RNase ,  mRNA ,  T cell receptor ,  autoimmune disease ,  knockout mouse ,  interleukin 6 ,  Thymus Gland ,  egg albumin ,  interferon gamma ,  Jurkat cell ,  gene targetting ,  HEK293 cell ,  transgenic mouse ,  *CD4-Positive T-Lymphocytes ,  *Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein ,  *MCPIP1 ,  3' Untranslated Regions ,  Gene Knockdown Technique ,  laboratory animal ,  Mus musculus
Semi thesaurus term： *CD4+ T-lymphocyte ,  *MALT1 ,  *Regnase-1 ,  3' untranslated regions ,  gene knockdown

JST classification (2)： Biological function  (EB03040U) ,  Immunological reaction in general  (ED03010T)

Terms in the title (5)： CD4+ ,  ヘルパーT細胞 ,  Regnase-1 ,  MALT1 ,  免疫活性化