Art

J-GLOBAL ID：201302204252742920   Reference number：13A0994027

MDR1 C3435T Polymorphism and Interaction with Environmental Factors in Risk of Parkinson’s Disease: A Case-control Study in Japan

パーキンソン病のリスクにおけるMDR1 C3435T多型と環境要因との相互作用:日本における症例対照研究

Author (17)： KIYOHARA Chikako (Dep. of Preventive Medicine, Graduate School of Medical Sciences, Kyushu Univ.) ,  MIYAKE Yoshihiro (Dep. of Preventive Medicine and Public Health, Fac. of Medicine, Fukuoka Univ.) ,  KOYANAGI Midori (Dep. of Cell Biology, Fac. of Medicine, Fukuoka Univ.) ,  FUJIMOTO Takahiro (Dep. of Cell Biology, Fac. of Medicine, Fukuoka Univ.) ,  SHIRASAWA Senji (Dep. of Cell Biology, Fac. of Medicine, Fukuoka Univ.) ,  TANAKA Keiko (Dep. of Preventive Medicine and Public Health, Fac. of Medicine, Fukuoka Univ.) ,  FUKUSHIMA Wakaba (Dep. of Public Health, Osaka City Univ. Graduate School of Medicine) ,  SASAKI Satoshi (Dep. of Social and Preventive Epidemiology, School of Public Health, The Univ. of Tokyo) ,  TSUBOI Yoshio (Dep. of Neurology, Fac. of Medicine, Fukuoka Univ.) ,  YAMADA Tatsuo (Dep. of Neurology, Fac. of Medicine, Fukuoka Univ.) ,  OEDA Tomoko (Clinical Res. Inst. and Dep. of Neurology, Utano National Hospital) ,  SHIMADA Hiroyuki (Dep. of Geriatrics and Neurology, Osaka City Univ. Graduate School of Medicine) ,  KAWAMURA Nobutoshi (Dep. of Neurology, Graduate School of Medical Sciences, Kyushu Univ.) ,  SAKAE Nobutaka (Dep. of Neurology, Graduate School of Medical Sciences, Kyushu Univ.) ,  FUKUYAMA Hidenao (Human Brain Res. Center, Kyoto Univ. Graduate School of Medicine) ,  HIROTA Yishio (Dep. of Public Health, Osaka City Univ. Graduate School of Medicine) ,  NAGAI Masaki (Dep. of Public Health, Saitama Medical Univ. Fac. of Medicine)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 28  Issue： 2  Page： 138-143 (J-STAGE)  Publication year： 2013 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： MDR1 ,...

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JST classification (1)： Basic neurology  (GN01020W)

Reference (37)：

• 1) Cordon-Cardo, C., O'Brien, J. P., Casals, D., Rittman-Grauer, L., Biedler, J. L., Melamed, M. R. and Bertino, J. R.: Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc. Natl. Acad. Sci. USA, 86: 695–698 (1989).
• 2) Gottesman, M. M. and Pastan, I.: Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem., 62: 385–427 (1993).
• 3) Schinkel, A. H., Wagenaar, E., van Deemter, L., Mol, C. A. and Borst, P.: Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest., 96: 1698–1705 (1995).
• 4) Mayer, U., Wagenaar, E., Beijnen, J. H., Smit, J. W., Meijer, D. K., van Asperen, J., Borst, P. and Schinkel, A. H.: Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein. Br. J. Pharmacol., 119: 1038–1044 (1996).
• 5) Schinkel, A. H., Mayer, U., Wagenaar, E., Mol, C. A., van Deemter, L., Smit, J. J., van der Valk, M. A., Voordouw, A. C., Spits, H., van Tellingen, O., Zijlmans, J. M., Fibbe, W. E. and Borst, P.: Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc. Natl. Acad. Sci. USA, 94: 4028–4033 (1997).

Terms in the title (8)： パーキンソン病 ,  リスク ,  MDR1 ,  多型 ,  環境要因 ,  相互作用 ,  日本 ,  症例対照研究