Art

J-GLOBAL ID：201302204252742920   Reference number：13A0994027

MDR1 C3435T Polymorphism and Interaction with Environmental Factors in Risk of Parkinson’s Disease: A Case-control Study in Japan

パーキンソン病のリスクにおけるMDR1 C3435T多型と環境要因との相互作用:日本における症例対照研究

Author (17)： KIYOHARA Chikako (Dep. of Preventive Medicine, Graduate School of Medical Sciences, Kyushu Univ.) ,  MIYAKE Yoshihiro (Dep. of Preventive Medicine and Public Health, Fac. of Medicine, Fukuoka Univ.) ,  KOYANAGI Midori (Dep. of Cell Biology, Fac. of Medicine, Fukuoka Univ.) ,  FUJIMOTO Takahiro (Dep. of Cell Biology, Fac. of Medicine, Fukuoka Univ.) ,  SHIRASAWA Senji (Dep. of Cell Biology, Fac. of Medicine, Fukuoka Univ.) ,  TANAKA Keiko (Dep. of Preventive Medicine and Public Health, Fac. of Medicine, Fukuoka Univ.) ,  FUKUSHIMA Wakaba (Dep. of Public Health, Osaka City Univ. Graduate School of Medicine) ,  SASAKI Satoshi (Dep. of Social and Preventive Epidemiology, School of Public Health, The Univ. of Tokyo) ,  TSUBOI Yoshio (Dep. of Neurology, Fac. of Medicine, Fukuoka Univ.) ,  YAMADA Tatsuo (Dep. of Neurology, Fac. of Medicine, Fukuoka Univ.) ,  OEDA Tomoko (Clinical Res. Inst. and Dep. of Neurology, Utano National Hospital) ,  SHIMADA Hiroyuki (Dep. of Geriatrics and Neurology, Osaka City Univ. Graduate School of Medicine) ,  KAWAMURA Nobutoshi (Dep. of Neurology, Graduate School of Medical Sciences, Kyushu Univ.) ,  SAKAE Nobutaka (Dep. of Neurology, Graduate School of Medical Sciences, Kyushu Univ.) ,  FUKUYAMA Hidenao (Human Brain Res. Center, Kyoto Univ. Graduate School of Medicine) ,  HIROTA Yishio (Dep. of Public Health, Osaka City Univ. Graduate School of Medicine) ,  NAGAI Masaki (Dep. of Public Health, Saitama Medical Univ. Fac. of Medicine)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 28  Issue： 2  Page： 138-143 (J-STAGE)  Publication year： 2013 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： MDR1 ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=13A0994027&from=J-GLOBAL&jstjournalNo=X0758A") }}

JST classification (1)： Basic neurology  (GN01020W)

Reference (37)：

• 1) Cordon-Cardo, C., O'Brien, J. P., Casals, D., Rittman-Grauer, L., Biedler, J. L., Melamed, M. R. and Bertino, J. R.: Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc. Natl. Acad. Sci. USA, 86: 695–698 (1989).
• 2) Gottesman, M. M. and Pastan, I.: Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem., 62: 385–427 (1993).
• 3) Schinkel, A. H., Wagenaar, E., van Deemter, L., Mol, C. A. and Borst, P.: Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest., 96: 1698–1705 (1995).
• 4) Mayer, U., Wagenaar, E., Beijnen, J. H., Smit, J. W., Meijer, D. K., van Asperen, J., Borst, P. and Schinkel, A. H.: Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein. Br. J. Pharmacol., 119: 1038–1044 (1996).
• 5) Schinkel, A. H., Mayer, U., Wagenaar, E., Mol, C. A., van Deemter, L., Smit, J. J., van der Valk, M. A., Voordouw, A. C., Spits, H., van Tellingen, O., Zijlmans, J. M., Fibbe, W. E. and Borst, P.: Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc. Natl. Acad. Sci. USA, 94: 4028–4033 (1997).

Terms in the title (8)： パーキンソン病 ,  リスク ,  MDR1 ,  多型 ,  環境要因 ,  相互作用 ,  日本 ,  症例対照研究