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J-GLOBAL ID：201302209129665140   Reference number：13A0528800

Serotype-independent Method of Recombinant Adeno-associated Virus (AAV) Vector Production and Purification

組み換えアデノ随伴ウイルス(AAV)ベクター生産と精製の血清型に依存した方法

Author (5)： MIYAKE Koichi (Nippon Medical School) ,  MIYAKE Noriko (Nippon Medical School) ,  YAMAZAKI Yoshiyuki (Nippon Medical School) ,  SHIMADA Takashi (Nippon Medical School) ,  HIRAI Yukihiko (Nippon Medical School)
Material： Journal of Nippon Medical School  (日本医科大学雑誌)
Volume： 79  Issue： 6  Page： 394-402 (J-STAGE)  Publication year： 2012 
JST Material Number： F0887A  ISSN： 1345-4676  CODEN： JNMSF5  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *vector(genetics) ,...
Semi thesaurus term： *adeno-associated virus vector ,...

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JST classification (1)： Gene manipulation  (EC02050B)

Reference (16)：

• 1. Nathwani AC, Tuddenham EG, Rangarajan S, et al.: Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. The New England journal of medicine 2011; 365: 2357-2365.
• 2. Bowles DE, McPhee SW, Li C, et al.: Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. Molecular therapy: the journal of the American Society of Gene Therapy 2012; 20: 443-455.
• 3. Flotte TR, Trapnell BC, Humphries M, et al.: Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing alpha1-antitrypsin: interim results. Human gene therapy 2011; 22: 1239-1247.
• 4. Wright JF, Qu G, Tang C, Sommer JM: Recombinant adeno-associated virus: formulation challenges and strategies for a gene therapy vector. Current opinion in drug discovery & development 2003; 6: 174-178.
• 5. Gao GP, Alvira MR, Wang L, Calcedo R, Johnston J, Wilson JM: Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. Proc Natl Acad Sci U S A 2002; 99: 11854-11859.

Terms in the title (5)： 組み換えアデノ随伴ウイルス ,  AAV ,  ベクター ,  精製 ,  血清型