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J-GLOBAL ID：201302211345682800   Reference number：13A1344345

Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells

アストリンとストレス顆粒によるmTOC1の抑制は癌細胞におけるアポトーシスを妨げる

Author (40)： THEDIECK Kathrin (Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  THEDIECK Kathrin (Bioinformatics and Molecular Genetics, Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  THEDIECK Kathrin (BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  THEDIECK Kathrin (Center for Systems Biology (ZBSA), Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  THEDIECK Kathrin (Renal Div., Univ. Hospital Freiburg, 79106 Freiburg, DEU) ,  HOLZWARTH Birgit (Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  HOLZWARTH Birgit (Bioinformatics and Molecular Genetics, Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  PRENTZELL Mirja Tamara (Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  PRENTZELL Mirja Tamara (Bioinformatics and Molecular Genetics, Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  PRENTZELL Mirja Tamara (Spemann Graduate School of Biology and Medicine (SGBM), Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  BOEHLKE Christopher (Renal Div., Univ. Hospital Freiburg, 79106 Freiburg, DEU) ,  KLAESENER Kathrin (Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  KLAESENER Kathrin (BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  KLAESENER Kathrin (Molecular Immunology, Max-Planck Inst. of Immunobiology and Epigenetics, 79108 Freiburg, DEU) ,  RUF Stefanie (Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  RUF Stefanie (Bioinformatics and Molecular Genetics, Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  RUF Stefanie (BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  RUF Stefanie (Res. Training Group (RTG) 1104, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  SONNTAG Annika Gwendolin (Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  SONNTAG Annika Gwendolin (Bioinformatics and Molecular Genetics, Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  MAERZ Lars (Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  MAERZ Lars (Bioinformatics and Molecular Genetics, Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  GRELLSCHEID Sushma-nagaraja (School of Biological and Biomedical Sciences, Durham Univ., Durham DH1 3LE, GBR) ,  KREMMER Elisabeth (Helmholtz Zentrum Muenchen, Inst. of Molecular Immunology, 81377 Munich, DEU) ,  NITSCHKE Roland (Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  NITSCHKE Roland (BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  NITSCHKE Roland (Center for Systems Biology (ZBSA), Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  KUEHN E. Wolfgang (BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  KUEHN E. Wolfgang (Renal Div., Univ. Hospital Freiburg, 79106 Freiburg, DEU) ,  JONKER Johan W. (Center for Liver, Digestive and Metabolic Diseases, Dep. of Pediatrics, Univ. of Groningen, Univ. Medical Center ...) ,  GROEN Albert K. (Center for Liver, Digestive and Metabolic Diseases, Dep. of Pediatrics, Univ. of Groningen, Univ. Medical Center ...) ,  RETH Michael (Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  RETH Michael (BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  RETH Michael (Molecular Immunology, Max-Planck Inst. of Immunobiology and Epigenetics, 79108 Freiburg, DEU) ,  HALL Michael N. (Biozentrum, Univ. of Basel, Klingelbergstrasse 50/70, 4056 Basel, CHE) ,  BAUMEISTER Ralf (Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  BAUMEISTER Ralf (Bioinformatics and Molecular Genetics, Fac. of Biology, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  BAUMEISTER Ralf (BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  BAUMEISTER Ralf (Center for Systems Biology (ZBSA), Albert-Ludwigs-University Freiburg, 79104 Freiburg, DEU) ,  BAUMEISTER Ralf (ZBMZ Center for Biochemistry and Molecular Cell Res., Fac. of Medicine, Albert-Ludwigs-University Freiburg, 79104 ...)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 154  Issue： 4  Page： 859-874  Publication year： Aug. 15, 2013 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： serine-threonine kinase ,  *protein complex ,  Apoptosis ,  *cytoplasmic granule ,  HeLa cell ,  tumor suppressor protein ,  *Proteins ,  subcellular distribution ,  enzyme activity ,  oxidation-reduction reaction ,  phosphorylation ,  oxidative stress ,  gene targetting ,  lysosome ,  MCF7 cell ,  *Stress Granules ,  IRS1 ,  intracellular localization ,  Tuberous Sclerosis Complex 1 Protein ,  Tuberous Sclerosis Complex 2 Protein ,  Gene Knockdown Technique
Semi thesaurus term： *mTOC1 ,  TSC1 ,  TSC2 ,  *アストリン ,  Raptor蛋白質 ,  gene knockdown

JST classification (2)： Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S)

Terms in the title (3)： ストレス顆粒 ,  癌細胞 ,  アポトーシス