Art

J-GLOBAL ID：201302212402434220   Reference number：13A1133116

Molecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of function

酸化誘導TDP-43 RRM1凝集および機能喪失の分子機構

Author (6)： CHANG Chung-Ke (Academia Sinica, Taipei, TWN) ,  CHIANG Ming-Hui (Academia Sinica, Taipei, TWN) ,  TOH Elsie Khai-Woon (Academia Sinica, Taipei, TWN) ,  HUANG Tai-Huang (Academia Sinica, Taipei, TWN) ,  CHANG Chi-Fon (Academia Sinica, Taipei, TWN) ,  HUANG Tai-Huang (National Taiwan Normal Univ., Taipei, TWN)
Material： FEBS Letters  (for the Rapid Publication of Short Reports in Biochemistry, Biophysics)
Volume： 587  Issue： 6  Page： 575-582  Publication year： 2013 
JST Material Number： D0575A  ISSN： 0014-5793  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *DNA binding protein ,  amino acid sequence ,  oxidation ,  amino acid ,  aggregation ,  conformational transition ,  mechanism ,  nervous system disease ,  folded structure ,  amino acid residue ,  hydrogen peroxide ,  visualization ,  NMR ,  aliphatic amine ,  thiol ,  aliphatic carboxylic acid ,  sulfur containing amino acid ,  primary amine
Semi thesaurus term： RNA recognition motif ,  *TDP-43 ,  Neurodegenerative Diseases ,  Protein misfolding ,  protein aggregation ,  Molecular Visualization ,  molecular mechanism

JST classification (1)： Proteins and peptides in general  (EB03010N)

Substance index (1)： Cysteine

Terms in the title (6)： 酸化 ,  誘導 ,  TDP-43 ,  RRM1 ,  凝集 ,  分子機構