Art

J-GLOBAL ID：201302228337574098   Reference number：13A0766974

Efficacy and safety of single-dose fosaprepitant in the prevention of chemotherapy-induced nausea and vomiting in patients receiving high-dose cisplatin: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial

大量シスプラチンを投与した患者の化学療法誘発吐き気と嘔吐の予防における単回投与ホスアプレピタントの有効性と安全性 多施設ランダム化二重盲検プラセボ比較第III相試験

Author (7)： SAITO H. (Aichi Cancer Center Aichi Hospital, Okazaki) ,  YOSHIZAWA H. (Niigata Univ. Medical and Dental Hospital, Niigata) ,  YOSHIMORI K. (Fukujuji Hospital, Kiyose) ,  KATAKAMI N. (Inst. Biomedical Res. and Innovation Hospital, Kobe) ,  KATSUMATA N. (Nippon Medical School, Kawasaki) ,  KAWAHARA M. (Otemae Hospital, Osaka) ,  EGUCHI K. (Teikyo Univ. School of Medicine, Tokyo, JPN)
Material： Annals of Oncology  (Ann Oncol)
Volume： 24  Issue： 4  Page： 1067-1073  Publication year： Apr. 2013 
JST Material Number： W0107A  ISSN： 0923-7534  CODEN： ANONE2  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： cisplatin ,...

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JST classification (2)： Clinical application of drugs acting on digestive system  (GW09020B) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Substance index (3)： Granisetron ,  Dexamethasone ,  Fosaprepitant

Reference (21)：

• Hesketh PJ. Chemotherapy-induced nausea and vomiting. N Engl J Med 2008;358: 2482-2494.
• Basch E, Prestrud AA, Hesketh PJ et al. Antiemetics: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 2011; 29: 4189-4198.
• Roila F, Herrstedt J, Aapro M et al. ESMO/MASCC Guidelines Working Group. Guideline update for MASCC and ESMO in the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting: results of the Perugia consensus conference. Ann Oncol 2010; 21(Suppl. 5): 232-243.
• NCCN Clinical Practice Guidelines in Oncology™. Antiemesis V.1. 2012.
• Hale JJ, Mills SG, MacCoss M et al. Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs. J Med Chem 2000; 43: 1234-1241.

Terms in the title (16)： シスプラチン ,  投与 ,  患者 ,  化学療法 ,  誘発 ,  吐き気と嘔吐 ,  予防 ,  単回投与 ,  ホスアプレピタント ,  有効性 ,  安全性 ,  施設 ,  ランダム化 ,  二重盲検 ,  プラセボ ,  第III相試験