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J-GLOBAL ID：201302235496756438   Reference number：13A0527865

Photodynamic Therapy in Combination with Talaporfin Sodium Induces Mitochondrial Apoptotic Cell Death Accompanied with Necrosis in Glioma Cells

タラポルフィンナトリウム併用光線力学療法は神経膠腫細胞においてネクローシスを伴うミトコンドリア介在性アポトーシス細胞死を誘導する

Author (8)： MIKI Yuichi (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  AKIMOTO Jiro (Dep. of Neurosurgery, Tokyo Medical Univ.) ,  YOKOYAMA Sakino (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  HOMMA Tomomi (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  TSUTSUMI Masateru (Dep. of Neurosurgery, Tokyo Medical Univ.) ,  HARAOKA Jo (Dep. of Neurosurgery, Tokyo Medical Univ.) ,  HIRANO Kazuya (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  BEPPU Masatoshi (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 36  Issue： 2  Page： 215-221 (J-STAGE)  Publication year： 2013 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： necrosis

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JST classification (3)： Tumors(=neoplasms)of nervous system  (GN04000V) ,  Experimental treatment for tumors  (GE02040Y) ,  Nervous system in general  (EJ12010J)

Substance index (1)： Talaporfin sodium

Reference (33)：

• 1) Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Holland E, Hess K, Michael C, Miller D, Sawaya R. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J. Neurosurg., 95, 190–198 (2001).
• 2) Namatame H, Akimoto J, Matsumura H, Haraoka J, Aizawa K. Photodynamic therapy of C6-implanted glioma cells in the rat brain employing second-generation photosensitizer talaporfin sodium. Photodiagn. Photodyn. Ther., 5, 198–209 (2008).
• 3) Sawaya R, Hammoud M, Schoppa D, Hess KR, Wu SZ, Shi WM, Wildrick DM. Neurosurgical outcomes in a modern series of 400 craniotomies for treatment of parenchymal tumors. Neurosurgery, 42, 1044–1055, discussion, 1055–1056 (1998).
• 4) Wilson CB. Glioblastoma: the past, the present, and the future. Clin. Neurosurg., 38, 32–48 (1992).
• 5) Perria C, Carai M, Falzoi A, Orunesu G, Rocca A, Massarelli G, Francaviglia N, Jori G. Photodynamic therapy of malignant brain tumors: clinical results of, difficulties with, questions about, and future prospects for the neurosurgical applications. Neurosurgery, 23, 557–563 (1988).

Terms in the title (9)： タラポルフィンナトリウム ,  併用 ,  光線力学療法 ,  神経膠腫 ,  細胞 ,  ネクローシス ,  ミトコンドリア ,  アポトーシス細胞死 ,  誘導