Art

J-GLOBAL ID：201302236301221230   Reference number：13A0216111

Bosentan increases serum IL-12 levels in systemic sclerosis patients with pulmonary arterial hypertension

肺動脈高血圧を伴う全身性硬化症患者において血清IL-12レベルを上昇させるボセンタン

Author (5)： TAKEHARA K ,  MATSUSHITA T ,  HASEGAWA M ,  FUJIMOTO M ,  HAMAGUCHI Y
Material： JOURNAL OF DERMATOLOGICAL SCIENCE
Volume： 55  Issue： 1  Page： 66-67  Publication year： 2009 
JST Material Number： O2147A  ISSN： 0923-1811  Document type： Article
Country of issue： Other (ZZZ)  Language： ENGLISH (EN)

Reference (10)：

• RUBIN, LJ. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med. 2002, 346, 896-903
• CUNNINGHAM, ME. Endothelin-1 and endothelin-4 stimulate monocyte production of cytokines. Crit Care Med. 1997, 25, 958-964
• Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the american rheumatism association diagnostic and therapeutic criteria committee. Arthritis Rheum. 1980, 23, 581-590
• TRINCHIERI, G. Interleukin-12 : a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of t-helper cells type 1 and cytotoxic lymphocytes. Blood. 1994, 84, 4008-4027
• MCMILLEN, MA. Endothelins : polyfunctional cytokines. J Am Coll Surg. 1995, 180, 621-637

Terms in the title (6)： 肺動脈高血圧 ,  全身性硬化症 ,  患者 ,  血清 ,  IL-12 ,  ボセンタン