Art

J-GLOBAL ID：201302245762270134   Reference number：13A0993918

Effects of Cyanamide, an Aldehyde Dehydrogenase Type 2 Inhibitor, on Glyceryl Trinitrate- and Isosorbide Dinitrate-Induced Vasodilation in Rabbit Excised Aorta and in Anesthetized Whole Animal

ウサギ摘出動脈と麻酔動物個体における三硝酸グリセリンおよび二硝酸イソソルビド誘発血管拡張に及ぼす2型アルデヒドデヒドロゲナーゼ阻害剤シアナミドの作用

Author (9)： ISHIBASHI Takaharu (Dep. of Pharmacology, School of Nursing, Kanazawa Medical Univ.) ,  ISHIBASHI Takaharu (School of Medicine, Kanazawa Medical Univ.) ,  NOMURA-NAKAMOTO Mihoko (School of Medicine, Kanazawa Medical Univ.) ,  ABE Fusae (School of Medicine, Kanazawa Medical Univ.) ,  MASUOKA Takayoshi (School of Medicine, Kanazawa Medical Univ.) ,  IMAIZUMI Noriko (School of Medicine, Kanazawa Medical Univ.) ,  YOSHIDA Junko (School of Medicine, Kanazawa Medical Univ.) ,  KAWADA Tomie (Dep. of Clinical Pharmacy, Fac. of Pharmaceutical Sciences, Niigata Univ. of Pharmacy and Applied Life Sciences) ,  NISHIO Matomo (School of Medicine, Kanazawa Medical Univ.)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 36  Issue： 4  Page： 556-563 (J-STAGE)  Publication year： 2013 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： hare ,...
Semi thesaurus term： Vasodilation ,...

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JST classification (1)： Basic research of cardioactive drugs  (GW07020N)

Substance index (2)： Isosorbide dinitrate ,  Nitroglycerin

Reference (34)：

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• 2) Munzel T, Feil R, Mulsch A, Lohmann SM, Hofmann F, Walter U. Physiology and pathophysiology of vascular signaling controlled by guanosine 3′,5′-cyclic monophosphate-dependent protein kinase [corrected]. Circulation, 108, 2172窶錀2183 (2003).
• 3) Chen Z, Stamler JS. Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase. Trends Cardiovasc. Med., 16, 259窶錀265 (2006).
• 4) Mayer B, Beretta M. The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles. Br. J. Pharmacol., 155, 170窶錀184 (2008).
• 5) Munzel T, Daiber A, Gori T. Nitrate therapy: new aspects concerning molecular action and tolerance. Circulation, 123, 2132窶錀2144 (2011).

Terms in the title (13)： ウサギ ,  摘出 ,  動脈 ,  麻酔 ,  動物 ,  個体 ,  三硝酸グリセリン ,  二硝酸イソソルビド ,  誘発 ,  血管拡張 ,  アルデヒドデヒドロゲナーゼ ,  阻害剤 ,  シアナミド