Art

J-GLOBAL ID：201302247901817227   Reference number：13A1192451

An Epithelial-Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

上皮間葉移行遺伝子の特徴により,EGFRおよびPI3K阻害剤に対する耐性が予測され,EGFR阻害剤耐性を克服するための治療標的としてのAxlが同定される

Author (34)： BYERS Lauren Averett (Univ. of Texas MD Anderson Cancer Center, Houston) ,  DIAO Lixia (Univ. of Texas MD Anderson Cancer Center, Houston) ,  WANG Jing (Univ. of Texas MD Anderson Cancer Center, Houston) ,  SAINTIGNY Pierre (Univ. of Texas MD Anderson Cancer Center, Houston) ,  GIRARD Luc (Univ. of Texas Southwestern, Texas) ,  PEYTON Michael (Univ. of Texas Southwestern, Texas) ,  SHEN Li (Univ. of Texas MD Anderson Cancer Center, Houston) ,  FAN Youhong (Univ. of Texas MD Anderson Cancer Center, Houston) ,  GIRI Uma (Univ. of Texas MD Anderson Cancer Center, Houston) ,  TUMULA Praveen K. (Univ. of Texas MD Anderson Cancer Center, Houston) ,  NILSSON Monique B. (Univ. of Texas MD Anderson Cancer Center, Houston) ,  GUDIKOTE Jayanthi (Univ. of Texas MD Anderson Cancer Center, Houston) ,  TRAN Hai (Univ. of Texas MD Anderson Cancer Center, Houston) ,  CARDNELL Robert J. G. (Univ. of Texas MD Anderson Cancer Center, Houston) ,  BEARSS David J. (Tolero Pharmaceuticals, Inc.) ,  WARNER Steven L. (Tolero Pharmaceuticals, Inc.) ,  FOULKS Jason M. (Astex Pharmaceuticals, Inc., Utah) ,  KANNER Steven B. (Astex Pharmaceuticals, Inc., Utah) ,  GANDHIA Varsha (Univ. of Texas MD Anderson Cancer Center, Houston) ,  KRETT Nancy (Northwestern Univ., Illinois) ,  ROSEN Steven T. (Northwestern Univ., Illinois) ,  KIM Edward S. (Univ. of Texas MD Anderson Cancer Center, Houston) ,  HERBST Roy S. (Univ. of Texas MD Anderson Cancer Center, Houston) ,  BLUMENSCHEIN George R. (Univ. of Texas MD Anderson Cancer Center, Houston) ,  LEE J. Jack (Univ. of Texas MD Anderson Cancer Center, Houston) ,  LIPPMAN Scott M. (Univ. of Texas MD Anderson Cancer Center, Houston) ,  ANG K. Kian (Univ. of Texas MD Anderson Cancer Center, Houston) ,  MILLS Gordon B. (Univ. of Texas MD Anderson Cancer Center, Houston) ,  HONG Waun K. (Univ. of Texas MD Anderson Cancer Center, Houston) ,  WEINSTEIN John N. (Univ. of Texas MD Anderson Cancer Center, Houston) ,  WISTUBA Ignacio I. (Univ. of Texas MD Anderson Cancer Center, Houston) ,  COOMBES Kevin R. (Univ. of Texas MD Anderson Cancer Center, Houston) ,  MINNA John D. (Univ. of Texas Southwestern, Texas) ,  HEYMACH John V. (Univ. of Texas MD Anderson Cancer Center, Houston)
Material： Clinical Cancer Research  (Clin Cancer Res)
Volume： 19  Issue： 1  Page： 279-290  Publication year： Jan. 01, 2013 
JST Material Number： W1296A  ISSN： 1078-0432  Document type： Article
Country of issue： United States (USA)  Language： ENGLISH (EN)

Terms in the title (10)： 上皮間葉移行 ,  遺伝子 ,  EGFR ,  PI3K阻害剤 ,  耐性 ,  予測 ,  EGFR阻害剤 ,  治療標的 ,  AXL ,  同定