Art

J-GLOBAL ID：201302251323459662   Reference number：13A0565975

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

遺伝子発現の配列特異的制御のためのRNA誘導プラットフォームとしてCRISPRの転用

Author (24)： QI Lei S. (UCSF Center for Systems and Synthetic Biology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  QI Lei S. (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  QI Lei S. (California Inst. for Quantitative Biomedical Res., San Francisco, CA 94158, USA) ,  LARSON Matthew H. (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  LARSON Matthew H. (Howard Hughes Medical Inst., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  LARSON Matthew H. (California Inst. for Quantitative Biomedical Res., San Francisco, CA 94158, USA) ,  GILBERT Luke A. (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  GILBERT Luke A. (Howard Hughes Medical Inst., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  GILBERT Luke A. (California Inst. for Quantitative Biomedical Res., San Francisco, CA 94158, USA) ,  DOUDNA Jennifer A. (Dep. of Molecular and Cellular Biology, Univ. of California, Berkeley, Berkeley, CA 94720, USA) ,  DOUDNA Jennifer A. (Dep. of Chemistry, Univ. of California, Berkeley, Berkeley, CA 94720, USA) ,  DOUDNA Jennifer A. (Howard Hughes Medical Inst., Univ. of California, Berkeley, Berkeley, CA 94720, USA) ,  DOUDNA Jennifer A. (California Inst. for Quantitative Biomedical Res., San Francisco, CA 94158, USA) ,  DOUDNA Jennifer A. (Physical Biosciences Div., Lawrence Berkeley National Lab., Berkeley, CA 94720, USA) ,  WEISSMAN Jonathan S. (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  WEISSMAN Jonathan S. (Howard Hughes Medical Inst., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  WEISSMAN Jonathan S. (California Inst. for Quantitative Biomedical Res., San Francisco, CA 94158, USA) ,  ARKIN Adam P. (Dep. of Bioengineering, Univ. of California, Berkeley, Berkeley, CA 94720, USA) ,  ARKIN Adam P. (California Inst. for Quantitative Biomedical Res., San Francisco, CA 94158, USA) ,  ARKIN Adam P. (Physical Biosciences Div., Lawrence Berkeley National Lab., Berkeley, CA 94720, USA) ,  LIM Wendell A. (UCSF Center for Systems and Synthetic Biology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  LIM Wendell A. (Dep. of Cellular and Molecular Pharmacology, Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  LIM Wendell A. (Howard Hughes Medical Inst., Univ. of California, San Francisco, San Francisco, CA 94158, USA) ,  LIM Wendell A. (California Inst. for Quantitative Biomedical Res., San Francisco, CA 94158, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 152  Issue： 5  Page： 1173-1183  Publication year： Feb. 28, 2013 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *gene expression ,  palindrome ,  endonuclease ,  Escherichia coli ,  *genetic technique ,  Proteins ,  Streptococcus pyogenes ,  transcription (genetics) ,  gene targetting ,  RNA polymerase ,  reporter gene ,  HEK293 cell ,  nucleotide sequence ,  Gene Silencing ,  Genetic Transcription Elongation ,  CRISPR ,  Cas9 protein ,  Gene Knockdown Technique ,  lacZ ,  *molecular genetic phenomenon ,  information ,  genetic information ,  sequence and arrangement ,  microorganism
Semi thesaurus term： CRISPR ,  Cas9 ,  *CRISPR干渉 ,  gene knockdown ,  LacZ gene

JST classification (2)： Research methods in genetics  (EC01020N) ,  Gene expression  (EC02040Q)

Terms in the title (5)： 遺伝子発現 ,  RNA ,  誘導 ,  プラットフォーム ,  CRISPR