Art

J-GLOBAL ID：201302254540684266   Reference number：13A1002802

The Effect of Heparin on Antigen-Induced Mucus Hypersecretion in the Nasal Epithelium of Sensitized Rats

感作ラットの鼻上皮における抗原誘発粘液分泌過多に対するヘパリンの効果

Author (3)： OGAWA Takao (Dep. of Otorhinolaryngology, Shiga Univ. of Medical Sci.) ,  SHIMIZU Shino (Dep. of Otorhinolaryngology, Shiga Univ. of Medical Sci.) ,  SHIMIZU Takeshi (Dep. of Otorhinolaryngology, Shiga Univ. of Medical Sci.)
Material： Allergology International  (Allergol Int)
Volume： 62  Issue： 1  Page： 77-83 (J-STAGE)  Publication year： 2013 
JST Material Number： L6446A  ISSN： 1323-8930  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Rattus ,...
Semi thesaurus term： Allergic inflammation ,...

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JST classification (1)： Basic research of anti-inflammatory drugs  (GW15010T)

Reference (30)：

• 1. Shimizu T, Hirano H, Majima Y, Sakakura Y. A mechanism of antigen-induced mucus production in nasal epithelium of sensitized rats. A comparison with lipopolysaccharide-induced mucus production. Am J Respir Crit Care Med 2000; 161: 1648-54.
• 2. Shimizu S, Shimizu T, Morser J et al. Role of the coagulation system in allergic inflammation in the upper airways. Clin Immunol 2008; 129: 365-71.
• 3. Shimizu S, Gabazza EC, Ogawa T et al. Role of thrombin in chronic rhinosinusitis-associated tissue remodeling. Am J Rhinol Allergy 2011; 25: 7-11.
• 4. Young E. The anti-inflammatory effects of heparin and related compounds. Thromb Res 2008; 122: 743-52.
• 5. Lever R, Page CP. Novel drug development opportunities for heparin. Nat Rev Drug Discov 2002; 1: 140-8.

Terms in the title (9)： 感作 ,  ラット ,  鼻 ,  上皮 ,  抗原 ,  誘発 ,  粘液 ,  分泌過多 ,  ヘパリン