Art

J-GLOBAL ID：201302264360154973   Reference number：13A0643600

Establishment of a stable T lymphoma cell line transduced with HLA-A*24:02-restricted WT1-specific TCR genes and its application to antigen-specific immunomonitoring

HLA-A*24.02制限性WT1特異的TCR遺伝子で形質導入した安定なTリンパ球細胞系列の樹立とその抗原特異的免疫モニタリングへの応用

Author (9)： WATANABE Kazue (Div. of Immunoregulation, Section of Disease Control, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo 060-0815, JPN) ,  WATANABE Kazue (Div. of Cancer Immunology, Medical and Biological Laboratories Co., Ltd., 1063-103, Ohara, Terasawaoka, Ina, Nagano ...) ,  TOJI Shingo (Div. of Cancer Immunology, Medical and Biological Laboratories Co., Ltd., 1063-103, Ohara, Terasawaoka, Ina, Nagano ...) ,  OHTAKE Junya (Div. of Immunoregulation, Section of Disease Control, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo 060-0815, JPN) ,  NAKANO Kiichiroh (Div. of Immunoregulation, Section of Disease Control, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo 060-0815, JPN) ,  SATOH Takayuki (Div. of ROYCE’ Health Bioscience, Section of Disease Control, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo ...) ,  KITAMURA Hidemitsu (Div. of Immunoregulation, Section of Disease Control, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo 060-0815, JPN) ,  NISHIMURA Takashi (Div. of Immunoregulation, Section of Disease Control, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo 060-0815, JPN) ,  NISHIMURA Takashi (Div. of ROYCE’ Health Bioscience, Section of Disease Control, Inst. for Genetic Medicine, Hokkaido Univ., Sapporo ...)
Material： Biomedical Research  (Biomed Res)
Volume： 34  Issue： 1  Page： 41-50 (J-STAGE)  Publication year： 2013 
JST Material Number： Z0236B  ISSN： 0388-6107  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Wilms Tumor ,...
Semi thesaurus term： *HLA-A*24.02 ,...

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JST classification (3)： Immunotherapy for tumors  (GE03035B) ,  Basic research of diagnostic drugs  (GW20010P) ,  Gene manipulation  (EC02050B)

Substance index (2)： L-Cys-L-Tyr-L-Thr-L-Trp-L-Asn-L-Gln-L-Met-L-Asn-L-Leu-OH ,  L-Cys-L-Met-L-Thr-L-Trp-L-Asn-L-Gln-L-Met-L-Asn-L-Leu-OH

Reference (33)：

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• 4. Cheever MA, Allison JP, Ferris AS, Finn OJ, Hastings BM, Hecht TT, Mellman I, Prindiville SA, Viner JL, Weiner LM and Matrisian LM (2009) The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research. Clin Cancer Res 15, 5323-5337.
• 5. Chhabra A, Yang L, Wang P, Comin-Anduix B, Das R, Chakraborty NG, Ray S, Mehrotra S, Yang H, Hardee CL, Hollis R, Dorsky DI, Koya R, Kohn DB, Ribas A, Economou JS, Baltimore D and Mukherji B (2008) CD4⁺CD25_- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model. J Immunol 181, 1063-1070.

Terms in the title (10)： HLA ,  制限 ,  WT1 ,  TCR遺伝子 ,  形質導入 ,  Tリンパ球 ,  細胞系列 ,  抗原 ,  免疫モニタリング ,  応用