Art

J-GLOBAL ID：201302265902186512   Reference number：13A1145539

Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells

B16メラノーマ細胞におけるメラニン形成阻害活性を持つハス(Nelumbo nucifera,スイレン科)の花芽と葉由来のアルカロイド成分

Author (15)： NAKAMURA Seikou (Dep. of Pharmacognosy, Kyoto Pharmaceutical Univ., Misasagi, Yamashina-ku, Kyoto 607-8412, JPN) ,  NAKASHIMA Souichi (Dep. of Pharmacognosy, Kyoto Pharmaceutical Univ., Misasagi, Yamashina-ku, Kyoto 607-8412, JPN) ,  TANABE Genzo (School of Pharmacy, Kinki Univ., 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, JPN) ,  ODA Yoshimi (Dep. of Pharmacognosy, Kyoto Pharmaceutical Univ., Misasagi, Yamashina-ku, Kyoto 607-8412, JPN) ,  YOKOTA Nami (Dep. of Pharmacognosy, Kyoto Pharmaceutical Univ., Misasagi, Yamashina-ku, Kyoto 607-8412, JPN) ,  FUJIMOTO Katsuyoshi (Dep. of Pharmacognosy, Kyoto Pharmaceutical Univ., Misasagi, Yamashina-ku, Kyoto 607-8412, JPN) ,  MATSUMOTO Takahiro (Dep. of Pharmacognosy, Kyoto Pharmaceutical Univ., Misasagi, Yamashina-ku, Kyoto 607-8412, JPN) ,  SAKUMA Rika (Dep. of Pharmacognosy, Kyoto Pharmaceutical Univ., Misasagi, Yamashina-ku, Kyoto 607-8412, JPN) ,  OHTA Tomoe (Dep. of Pharmacognosy, Kyoto Pharmaceutical Univ., Misasagi, Yamashina-ku, Kyoto 607-8412, JPN) ,  OGAWA Keiko (Dep. of Pharmacognosy, Kyoto Pharmaceutical Univ., Misasagi, Yamashina-ku, Kyoto 607-8412, JPN) ,  NISHIDA Shino (Dep. of Pharmacognosy, Kyoto Pharmaceutical Univ., Misasagi, Yamashina-ku, Kyoto 607-8412, JPN) ,  MIKI Hisako (Dep. of Pharmacognosy, Kyoto Pharmaceutical Univ., Misasagi, Yamashina-ku, Kyoto 607-8412, JPN) ,  MATSUDA Hisashi (Dep. of Pharmacognosy, Kyoto Pharmaceutical Univ., Misasagi, Yamashina-ku, Kyoto 607-8412, JPN) ,  MURAOKA Osamu (School of Pharmacy, Kinki Univ., 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, JPN) ,  YOSHIKAWA Masayuki (Dep. of Pharmacognosy, Kyoto Pharmaceutical Univ., Misasagi, Yamashina-ku, Kyoto 607-8412, JPN)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 21  Issue： 3  Page： 779-787  Publication year： Feb. 01, 2013 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *Melanoma ,  biosynthesis ,  *pharmacological action ,  *Nelumbo ,  flower bud ,  leaf ,  *alkaloid ,  natural material ,  space structure ,  Structure-Activity Relationship ,  inhibition ,  transcription (genetics) ,  cultured cell ,  tumor cell ,  toxicity test ,  monophenol monooxygenase ,  biopigment ,  chemical synthesis ,  cytotoxicity ,  antitumor drug ,  oxidase ,  isomerase ,  inhibition of transcription ,  50% inhibitory concentration ,  melanin biosynthesis ,  *melanogenesis inhibiting action ,  *eudicotyledons
Semi thesaurus term： B16メラノーマ4A5細胞 ,  IC50 ,  チロシナーゼ関連蛋白質1 ,  チロシナーゼ関連蛋白質2 ,  melanization ,  *melanogenesis inhibition

JST classification (6)： Structure-activity relationship of drugs  (GV01050B) ,  Synthesis of drugs  (GV01030F) ,  Basic oncology in general  (GE02010R) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of pharmacology of crude drugs  (GX06020J) ,  Skin tumors(=neoplasms)  (GF04000X)

Substance index (7)： (-)-Lirinidine ,  1-Benzyl-1,2,3,4-tetrahydro-2-methylisoquinoline ,  2-Hydroxy-1-methoxy-6a,7-dehydroaporphine ,  2-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline ,  Aporphine ,  N-Methylasimilobine ,  Nuciferine

Terms in the title (9)： B16メラノーマ ,  細胞 ,  メラニン形成 ,  阻害活性 ,  ハス ,  スイレン科 ,  花芽 ,  葉 ,  アルカロイド