Art

J-GLOBAL ID：201302266808081797   Reference number：13A0991948

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

CRISPR/Casシステムを用いたゲノム工学による複数の遺伝子に変異を持つマウスの1段階作製法

Author (11)： WANG Haoyi (Whitehead Inst. for Biomedical Res., Cambridge, MA 02142, USA) ,  YANG Hui (Whitehead Inst. for Biomedical Res., Cambridge, MA 02142, USA) ,  SHIVALILA Chikdu S. (Whitehead Inst. for Biomedical Res., Cambridge, MA 02142, USA) ,  SHIVALILA Chikdu S. (Dep. of Biology, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  DAWLATY Meelad M. (Whitehead Inst. for Biomedical Res., Cambridge, MA 02142, USA) ,  CHENG Albert W. (Whitehead Inst. for Biomedical Res., Cambridge, MA 02142, USA) ,  CHENG Albert W. (Computational and Systems Biology Program, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  ZHANG Feng (McGovern Inst. for Brain Res., Dep. of Brain and Cognitive Sciences, Dep. of Biological Engineering, Massachusetts ...) ,  ZHANG Feng (Broad Inst. of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA) ,  JAENISCH Rudolf (Whitehead Inst. for Biomedical Res., Cambridge, MA 02142, USA) ,  JAENISCH Rudolf (Computational and Systems Biology Program, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 153  Issue： 4  Page： 910-918  Publication year： May. 09, 2013 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *gene expression ,  *immunity ,  ES cell ,  mouse(animal) ,  point mutation ,  DNA strand break ,  DNA repair ,  homologous recombination ,  RNA editing ,  *gene targetting
Semi thesaurus term： *CRISPR-Cas Systems ,  mouse embryonic stem cell ,  NHEJ

JST classification (2)： Gene manipulation  (EC02050B) ,  Laboratry organisms  (EA03070Y)

Terms in the title (8)： CRISPR ,  CAS ,  ゲノム工学 ,  遺伝子 ,  変異 ,  マウス ,  段階 ,  作製法