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J-GLOBAL ID：201302266879170294   Reference number：13A1465658

A diagnostic conundrum: heterophilic antibody interference in an adrenocorticotropic hormone immunoassay not detectable using a proprietary heterophile blocking reagent

診断上の難問:独占所有権のある異好性ブロッキング試薬を用い検出できない副腎皮質刺激ホルモンにおける異好性抗体干渉

Author (8)： GRASKO Jonathan (QE2 Medical Center, Nedlands, AUS) ,  WILLLIAMS Robin (Fremantle Hospital, Fremantle, AUS) ,  BEILIN Jonathan (Royal Perth Hospital, Perth, AUS) ,  GLENDENNING Paul (Royal Perth Hospital, Perth, AUS) ,  GLENDENNING Paul (Univ. Western Australia, Perth, AUS) ,  FERMOYLE Soraya (Royal Perth Hospital, Perth, AUS) ,  VASIKARAN Samuel (Royal Perth Hospital, Perth, AUS) ,  VASIKARAN Samuel (Univ. Western Australia, Perth, AUS)
Material： Annals of Clinical Biochemistry  (Ann Clin Biochem)
Volume： 50  Issue： 5  Page： 433-437  Publication year： Sep. 2013 
JST Material Number： B0921B  ISSN： 0004-5632  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： drug ,...
Semi thesaurus term： antagonist ,...

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JST classification (3)： Endocrine system diagnosis  (GL02000B) ,  Pituitary hormones  (EB08060Z) ,  Biochemistry of antigens,antibodies,complements  (ED04020L)

Reference (12)：

• Berson SA, Yalow RS, Bauman A, et al. Insulin-I131 metabolism in human subjects: demonstration of insulin binding globulin in the circulation of insulin treated subjects. J Clin Invest 1956; 35: 170-190.
• Bolstad N, Warren DJ, Bjerner J, et al. Heterophilic antibody interference in commercial immunoassays; a screening study using paired native and pre-blocked sera. Clin Chem Lab Med 2011; 49: 2001-2006.
• Kricka LJ. Human anti-animal antibody interferences in immunological assays. Clin Chem 1999; 45: 942-956.
• Preissner CM, O'Kane DJ, Singh RJ, et al. Phantoms in the assay tube: heterophile antibody interferences in serum thyroglobulin assays. J Clin Endocrinol Metab 2003; 88: 3069-3074.
• Saleem M, Lewis JG, Florkowski CM, et al. A patient with pseudo-Addison's disease and falsely elevated thyroxine due to interference in serum cortisol and free thyroxine immunoassays by two different mechanisms. Ann Clin Biochem 2009; 46: 172-175.

Terms in the title (8)： 診断 ,  独占 ,  所有権 ,  ブロッキング ,  試薬 ,  副腎皮質刺激ホルモン ,  異好性抗体 ,  干渉