Art

J-GLOBAL ID：201302269931002388   Reference number：12A1799166

NDRG4 protects cerebral neurons against severe ischemic stress

虚血に対して保護的作用を示す細胞内タンパク質NDRG4

Author (1)： IMOTO(YAMAMOTO) HITOMI (国立循環器病研究センター・分子病態部)
Material： 日本血栓止血学会誌  (Japanese Journal of Thrombosis and Hemostasis)
Volume： 23  Issue： 4  Page： 399-406 (J-STAGE)  Publication year： 2012 
JST Material Number： L2757A  ISSN： 0915-7441  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *ischemia ,...
Semi thesaurus term： Activating transcription factor-4 ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=12A1799166&from=J-GLOBAL&jstjournalNo=L2757A") }}

JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic neurology  (GN01020W)

Substance index (1)： Homocysteine

Reference (33)：

• 1) Kokame K, Kato H, Miyata T : Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. J Biol Chem 271 : 29659-29665, 1996.
• 2) Yamamoto H, Kokame K, Okuda T, Nakajo Y, Yanamoto H, Miyata T : NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia. J Biol Chem 286 : 26158-26165, 2011.
• 3) Okuda T, Kondoh H : Identification of new genes Ndr2 and Ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem Biophys Res Commun 266 : 208-215, 1999.
• 4) Zhou RH, Kokame K, Tsukamoto Y, Yutani C, Kato H, Miyata T : Characterization of the human NDRG gene family : a newly identified member, NDRG4, is specifically expressed in brain and heart. Genomics 73 : 86-97, 2001.
• 5) Melotte V, Qu X, Ongenaert M, van Criekinge W, de Bruine AP, Baldwin HS, van Engeland M : The N-myc downstream regulated gene (NDRG) family : diverse functions, multiple applications. FASEB J 24 : 4153-4166, 2010.

Terms in the title (2)： 虚血 ,  タンパク質