Art

J-GLOBAL ID：201302272643963803   Reference number：13A0994688

Anti-MDA5 (melanoma differentiation-associated gene 5) antibody and dermatomyositis with rapidly progressive interstitial pneumonia

抗MDA5(melanoma differentiation-associated gene 5)抗体と皮膚筋炎・急速進行性間質性肺炎

Author (2)： NAKASHIMA RAN (京都大学医学部附属病院 免疫・膠原病内科) ,  MIMORI TSUNEYO (京都大学大学院医学研究科臨床免疫学)
Material： 日本臨床免疫学会会誌  (Japanese Journal of Clinical Immunology)
Volume： 36  Issue： 2  Page： 71-76 (J-STAGE)  Publication year： 2013 
JST Material Number： X0337A  ISSN： 0911-4300  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： adaptor protein ,...
Semi thesaurus term： IL12 ,...

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JST classification (2)： Clinical medicine on musculoskeletal system in general  (GG01030M) ,  Clinical medicine on respiratory system in general  (GI01030S)

Substance index (1)： Cyclophosphamid

Reference (17)：

• 1) Sato S, Hirakata M, Kuwana M, et al. : Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis. Arthritis Rheum. 52 : 1571-1576, 2005.
• 2) Sato S, Hoshino K, Satoh T, et al. : RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis : Association with rapidly progressive interstitial lung disease. Arthritis Rheum. 60 : 2193-2200, 2009.
• 3) Nakashima R, Imura Y, Kobayashi S, et al. : The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody. Rheumatology (Oxford). 49 : 433-440, 2010.
• 4) Kato H, Takeuchi O, Sato S, et al. : Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 441 : 101-105, 2006.
• 5) Nawata Y, Kurasawa K, Takabayashi K, et al. : Corticosteroid resistant interstitial pneumonitis in dermatomyositis/polymyositis : prediction and treatment with cyclosporine. J Rheumatol. 26 : 1527-1533, 1999.

Terms in the title (4)： MDA5 ,  抗体 ,  皮膚筋炎 ,  急速進行性間質性肺炎