Art

J-GLOBAL ID：201302279582472199   Reference number：13A0643490

Model-based Dose Selection for Phase III Rivaroxaban Study in Japanese Patients with Non-valvular Atrial Fibrillation

非弁膜症性心房細動の日本人患者における第III相リバロキサバン研究のためのモデルに基づいた用量選択

Author (8)： TANIGAWA Takahiko (Dev. Clinical Pharmacology Asia, Bayer Yakuhin Ltd.) ,  KANEKO Masato (Dev. Clinical Pharmacology Asia, Bayer Yakuhin Ltd.) ,  HASHIZUME Kensei (Dev. Clinical Pharmacology Asia, Bayer Yakuhin Ltd.) ,  KAJIKAWA Mariko (Clinical Dev. Cardiovascular, Bayer Yakuhin Ltd.) ,  UEDA Hitoshi (Medical Scientific Liaison, Bayer Yakuhin Ltd.) ,  TAJIRI Masahiro (Clinical Dev. Cardiovascular, Bayer Yakuhin Ltd.) ,  PAOLINI John F. (Bayer HealthCare Pharmaceuticals) ,  MUECK Wolfgang (Dev. Clinical Pharmacology, Bayer HealthCare AG)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 28  Issue： 1  Page： 59-70 (J-STAGE)  Publication year： 2013 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *auricular fibrillation ,...
Semi thesaurus term： Factor Xa ,...

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JST classification (3)： Drug therapy(=pharmacotherapy)for nervous system diseases  (GN05020Y) ,  Clinical application of drugs acting on blood and body fluid  (GW14020X) ,  Clinical biopharmacy  (GY01022L)

Substance index (1)： Rivaroxaban

Reference (45)：

• 1) Ohsawa, M., Okayama, A., Sakata, K., Kato, K., Itai, K., Onoda, T. and Ueshima, H.: Rapid increase in estimated number of persons with atrial fibrillation in Japan: an analysis from national surveys on cardiovascular diseases in 1980, 1990 and 2000. J. Epidemiol., 15: 194–196 (2005).
• 2) Tanizaki, Y., Kiyohara, Y., Kato, I., Iwamoto, H., Nakayama, K., Shinohara, N., Arima, H., Tanaka, K., Ibayashi, S. and Fujishima, M.: Incidence and risk factors for subtypes of cerebral infarction in a general population: the Hisayama study. Stroke, 31: 2616–2622 (2000).
• 3) Stroke Risk in Atrial Fibrillation Working Group: Independent predictors of stroke in patients with atrial fibrillation: a systematic review. Neurology, 69: 546–554 (2007).
• 4) Lutz, W., Sanderson, W. and Scherbov, S.: The coming acceleration of global population ageing. Nature, 451: 716–719 (2008).
• 5) World Health Organization: World Population Ageing 1950–2050; Chapter IV. Demographic Profile of the Older Population. http://www.un.org/esa/population/publications/worldageing19502050/pdf/90chapteriv.pdf (updated 2009; last accessed 10 January 2011).

Terms in the title (7)： 非弁膜症性心房細動 ,  日本人 ,  患者 ,  リバロキサバン ,  研究 ,  モデル ,  用量